A5V4d
A5V4d A5V4d
Feverish illness in children Number of studies Number of children Effect Quality Activity 1 (Hay et al., 2009) Appetite 1 (Hay et al., 2009) Sleep 1 (Hay et al., 2009) 222 Combined Mono Relative (95% confidence interval) 37 of 51 a 32 of 52 a 27 of 51 a Mean change temperature at 1 to 2 hours 1 hour 1 (Erlewyn- Lajeunesse et al., 2006) -1.22 (0.95 to 1.50) n = 36 c 39 of 46 b 29 of 49 b 25 of 50 b Mean change in temperature at > 2 to 5 hours No data Mean change in temperature at > 5 to 24 hours No data Mean change in temperature at > 24 hours No data Mean temperature at 1 to 2 hours 1 hour 1 (Erlewyn- Lajeunesse et al., 2006) 37.59°C (SD 0.61) c 1 (Paul et al., 2010) 37.4°C (SD 0.5), n = 20 e 2 hours 1 (Paul et al., 2010) 37.0°C (SD 0.5), n = 20 e Mean temperature at > 2 to 5 hours 3 hours 1 (Paul et al., 2010) 36.9°C (SD 0.4), n = 20 e -0.92 (0.70 to 1.14), n = 35 d 37.81°C (SD 0.69) d 37.6°C (SD 0.5), n = 20 f 37.1°C (SD 0.4), n = 20 f 37.2°C (SD 0.6), n = 20 f Absolute (95% confidence interval) RR 0.86 (0.69 to 1.05) - Low RR 1.04 (0.76 to 1.43) - Low RR 1.06 (0.72 to 1.55) - Low SMD -0.33 (-0.80 to +0.13) SMD -0.33 (-0.80 to +0.13) Adjusted MD = 0.25C (-0.01 to 0.50), P = 0.166 SMD -0.39 (-1.02 to +0.23) SMD -0.22 (-0.84 to +0.41) SMD -0.58 (-1.21 to +0.06) - Moder ate - Moder ate - - -
Antipyretic interventions Number of studies Number of children Effect Quality 4 hours 1 (Paul et al., 2010) 36.9°C (SD 0.3), n = 20 e 5 hours 1 (Paul et al., 2010) 36.9°C (SD 0.5), n = 20 e Mean temperature at > 5 to 24 hours 6 hours 1 (Paul et al., 2010) 37.2°C (SD 0.6), n = 20 e 24 hours 1 (Hay et al., 2009) 36.6°C (SD 1.01), n = 52a Mean temperature at > 24 hours 1 (Hay et al., 2009) 36.0°C (SD 0.66), n = 52 a Afebrile at 1 to 2 hours 1 hour 1 (Paul et al., 2010) 18 of 20 e 2 hours Combined Mono Relative (95% confidence interval) 37.5°C (SD 1.1), n = 20 f 38.0°C (SD 1.1), n = 20 f 38.5°C (SD 1.5), n = 20 f 36.4°C (SD 0.85), n = 52 b 36.1°C (SD 0.78), n = 52 b 16 of 20 f SMD -0.73 (-1.37 to -0.09) SMD -1.26 (-1.95 to -0.58) SMD -1.12 (-1.79 to -0.44) SMD 0.21 (-0.17 to +0.60) SMD -0.14 (-0.52 to +0.25) 1 (Hay et al., 2009) 47 of 52 a 44 of 52 b SMD 1.07 (+0.92 to +1.24) 1 (Paul et al., 2010) 20 of 20f l Afebrile at > 2 to 5 hours 3 hours 1 (Paul et al., 2010) 20 of 20 e 4 hours 1 (Hay et al., 2009) 51 of 52 el 1 (Paul et al., 2010) 20 of 20 e 5 hours 1 (Paul et al., 2010) 20 of 20 e 19 of 20 f 18 of 20 f 44 of 52 f 14 of 20 f 12 of 20 f Absolute (95% confidence interval) - - - - Moder ate - Moder ate RR 1.13 (0.86 to 1.46) - Very low - Moder ate RR 1.05 (0.92 to 1.20) - Low RR 1.11 (0.93 to1.31) - Very low RR 1.16 (1.03 to 1.31) - Moder ate RR 1.41 (1.05 to 1.90) - Low RR 1.64 (1.15 to 2.35) - Low 223
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Antipyretic interventions<br />
Number of studies Number of children Effect Quality<br />
4 hours<br />
1 (Paul et al., 2010) 36.9°C (SD<br />
0.3),<br />
n = 20 e<br />
5 hours<br />
1 (Paul et al., 2010) 36.9°C (SD<br />
0.5),<br />
n = 20 e<br />
Mean temperature at > 5 to 24 hours<br />
6 hours<br />
1 (Paul et al., 2010) 37.2°C (SD<br />
0.6), n = 20 e<br />
24 hours<br />
1 (Hay et al., 2009) 36.6°C (SD<br />
1.01), n = 52a<br />
Mean temperature at > 24 hours<br />
1 (Hay et al., 2009) 36.0°C (SD<br />
0.66), n = 52 a<br />
Afebrile at 1 to 2 hours<br />
1 hour<br />
1 (Paul et al., 2010) 18 of 20 e<br />
2 hours<br />
Combined Mono Relative<br />
(95% confidence<br />
interval)<br />
37.5°C (SD<br />
1.1),<br />
n = 20 f<br />
38.0°C (SD<br />
1.1),<br />
n = 20 f<br />
38.5°C (SD<br />
1.5), n = 20 f<br />
36.4°C (SD<br />
0.85), n = 52 b<br />
36.1°C (SD<br />
0.78), n = 52 b<br />
16 of 20 f<br />
SMD -0.73 (-1.37 to<br />
-0.09)<br />
SMD -1.26 (-1.95 to<br />
-0.58)<br />
SMD -1.12 (-1.79 to<br />
-0.44)<br />
SMD 0.21 (-0.17 to<br />
+0.60)<br />
SMD -0.14 (-0.52 to<br />
+0.25)<br />
1 (Hay et al., 2009) 47 of 52 a 44 of 52 b SMD 1.07 (+0.92 to<br />
+1.24)<br />
1 (Paul et al., 2010) 20 of 20f l<br />
Afebrile at > 2 to 5 hours<br />
3 hours<br />
1 (Paul et al., 2010) 20 of 20 e<br />
4 hours<br />
1 (Hay et al., 2009) 51 of 52 el<br />
1 (Paul et al., 2010) 20 of 20 e<br />
5 hours<br />
1 (Paul et al., 2010) 20 of 20 e<br />
19 of 20 f<br />
18 of 20 f<br />
44 of 52 f<br />
14 of 20 f<br />
12 of 20 f<br />
Absolute<br />
(95%<br />
confidence<br />
interval)<br />
-<br />
-<br />
-<br />
- Moder<br />
ate<br />
- Moder<br />
ate<br />
RR 1.13 (0.86 to 1.46) - Very<br />
low<br />
- Moder<br />
ate<br />
RR 1.05 (0.92 to 1.20) - Low<br />
RR 1.11 (0.93 to1.31) - Very<br />
low<br />
RR 1.16 (1.03 to 1.31) - Moder<br />
ate<br />
RR 1.41 (1.05 to 1.90) - Low<br />
RR 1.64 (1.15 to 2.35) - Low<br />
223
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