A5V4d

Antipyretic interventions
AUC area under the curve, NC non-calculable, NR not reported, NS Not significant at P < 0.05, P probability, SD standard
deviation, SMD standard mean difference
a Alternating acetaminophen (12.5 mg/kg) with ibuprofen (5 mg/kg) every 4 hours
b Acetaminophen (12.5 mg/kg) every 6 hours
c Alternating ibuprofen (10 mg/kg) with acetaminophen (15 mg/kg) every 4 hours
d Acetaminophen (15 mg/kg) every 4 hours
e Alternating acetaminophen (15 mg/kg) with ibuprofen (10 mg/kg) with) every 3 hours
Table 9.7 GRADE findings for ibuprofen vs. paracetamol and ibuprofen combined
Number of studies Number of children Effect Quality
Discomfort at 1 to 2 hours
No data
Discomfort at > 2 to 5 hours
No data
Discomfort at > 5 to 24 hours
24 hours
Discomfort
1 (Hay et al., 2009)
Activity
1 (Hay et al., 2009)
Appetite
1 (Hay et al., 2009)
Sleep
1 (Hay et al., 2009)
Discomfort > 24 hours
48 hours
Comfort
1 (Hay et al., 2009)
Activity
1 (Hay et al., 2009)
Appetite
1 (Hay et al., 2009)
Sleep 1 (Hay et al.,
2009)
Day 5
Comfort
1 (Hay et al., 2009)
Combined Mono Relative
(95% confidence
interval)
29 of 50 a
23 of 48 a
14 of 48 a
20 of 52 a
36 of 52 a
28 of 52 a
21 of 51 a
25 of 52 a
38 of 50 a
36 of 52 b
20 of 34 b
14 of 52 b
13 of 26 b
37 of 52 b
37 of 51 b
22 of 50 b
31 of 51 b
38 of 47 b
RR 0.84 (0.62 to 1.13)
RR 0.81 (0.54 to 1.22)
RR 1.08 (0.58 to 2.03)
Absolute
(95%
confidence
interval)
- Low
- Very
low
- Very
low
RR 0.77 (0.46 to 1.29) - Very
low
RR 0.97 (0.76 to 1.25)
Adjusted OR 0.89
(0.32 to 2.43)
- Moder
ate
RR 0.74 (0.55 to 1.00) - Moder
ate
RR 0.94 (0.59 to 1.47) - Very
low
RR 0.79 (0.55 to 1.13) - Low
RR 0.94 (0.76 to 1.16) - Moder
ate
221