A5V4d

Feverish illness in children
Number of studies Number of children Effect Quality
5 hours
1 (Pashapour et al.,
2009)
1 (Kramer et al.,
2008)
220
Alternating Paracetamol Relative
(95% confidence
interval)
38.0°C (SD
0.47), n = 35 c
37.1°C (SD
0.6224), n = 19 e
Mean temperature at > 5 to 24 hours
6 hours
1 (Kramer et al.,
2008)
7 hours
1 (Pashapour et al.,
2009)
8 hours
1 (Pashapour et al.,
2009)
37.4°C (SD
0.8299), n = 19 e
38.0°C (SD
0.48), n = 35 c
37.7°C (SD
0.46), n = 35 c
Mean temperature at > 24 hours
Day 1
1 (Sarrell et al.,
2006)
Day 2
1 (Sarrell et al.,
2006)
Day 3
1 (Sarrell et al.,
2006)
Afebrile at 1 to 2 hours
No data
Afebrile at > 2 to 5 hours
No data
Afebrile at > 5 to 24 hours
No data
Afebrile at > 24 hours
No data
Temperature AUC
No data
Adverse events
No reported
39.64°C (SD
1.17), n = 155 a
38.78°C (SD
0.87), n = 155 a
38.54°C (SD
0.74), n = 155 a
38.2°C (SD
0.38), n = 35 d
37.9°C (SD
0.8299), n = 19 d
37.5°C (SD
0.8299), n = 19 d
38.2°C (SD
0.57), n = 35 d
38.0°C (SD
0.52), n = 35 d
40.55°C (SD
1.31), n = 155 b
39.74°C (SD
1.37), n = 155 b
39.34°C (SD
1.19), n = 155 b
SMD -0.46 (-0.94 to
+0.01)
SMD -1.07 (-1.75 to
-0.38)
SMD -0.12 (-0.75 to
+0.52)
SMD -0.38 (-0.85 to
+0.10)
SMD -0.60 (-1.08 to
-0.12)
SMD -0.73 (-0.96 to
-0.50)
SMD -0.83 (-1.07 to
-0.60)
SMD -0.81 (-1.04 to
-0.57)
Absolute
(95%
confidence
interval)
- Very
low
- Very
low
-
- Moder
ate
- Moder
ate
- High
- High
- High