A5V4d

Table 9.6 GRADE findings for paracetamol vs. paracetamol and ibuprofen alternating
Antipyretic interventions
Number of studies Number of children Effect Quality
Discomfort at 1 to 2 hours
No data
Discomfort at > 2 to 5 hours
No data
Discomfort at > 5 to 24 hours
Day 1
1 (Sarrell et al.,
2006)
Discomfort > 24 hours
Day 2
1 (Sarrell et al.,
2006)
Day 3
1 (Sarrell et al.,
2006)
Alternating Paracetamol Relative
(95% confidence
interval)
9.26 (SD 2.49),
n = 155 a
5.09 (SD 2.78),
n = 155 a
4.18 (SD 2.74),
n = 155 a
Mean change temperature at 1 to 2 hours
No data
Mean change in temperature at > 2 to 5 hours
No data
Mean change in temperature at > 5 to 24 hours
No data
Mean change in temperature at > 24 hours
No data
Mean temperature at 1 to 2 hours
1 (Pashapour et al.,
2009)
38.8°C (SD
0.59), n = 35 c
Mean temperature at > 2 to 5 hours
3 hours
1 (Kramer et al.,
2008)
4 hours
1 (Pashapour et al.,
2009)
1 (Kramer et al.,
2008)
37.7°C (SD
0.6224), n = 19 e
38.4°C (SD
0.34), n = 35 c
37.4°C (SD
0.8299), n = 19 e
11.77 (SD 2.64),
n = 154 b
8.87 (SD 2.54),
n = 154 b
7.66 (SD 2.96),
n = 154 b
38.8°C (SD
0.47), n = 35 d
37.7°C (SD
0.415), n = 19 d
38.5°C (SD 0.3),
n = 35 d
38.0°C (SD
1.0374), n = 19 d
SMD -0.98 (-1.21 to
-0.74)
SMD -1.42 (-1.67 to
-1.17)
SMD -1.22 (-1.46 to
-0.97)
SMD 0.00 (-0.47 to
+0.47)
SMD 0.00 (-0.64 to
+0.64)
SMD -0.31 (-0.78 to
+0.16)
SMD -0.63 (-1.28 to
+0.03)
Absolute
(95%
confidence
interval)
- High
- High
- High
- Low
- Very
low
- Very
low
- Very
low
219