A5V4d

Feverish illness in children
Number of studies Number of children Effect Quality
Afebrile at > 5 to 24 hours
6 hours
218
Combined
1 (Hay et al., 2009) 47 of 52 a
8 hours
1 (Hay et al., 2009) 45 of 52 a
12 hours
1 (Hay et al., 2009) 49 of 52 a
Afebrile at > 24 hours
1 (Hay et al., 2009) 47 of 52 a
Time without fever
0 to 4 hours
Mono Relative
(95% confidence
interval)
39 of 52 b
42 of 52 b
39 of 52 b
46 of 52 b
1 (Hay et al., 2009) 116.2 (SD 65.0) a 171.1 (SD 40.8)
b
24 hours
1 (Hay et al., 2009) 1217.4 (SD
237.6) a
Adverse events
Diarrhoea
1 (Hay et al., 2009) 12 of 52 a
Vomiting
1 (Hay et al., 2009) 2 of 52 a
940.3 (SD
362.9) b
10 of 52 b
6 of 52
Absolute
(95%
confidence
interval)
RR 1.21 (1.01 to 1.44) - Moder
ate
RR 1.07 (0.90 to 1.27) - Moder
ate
RR 1.26 (1.06 to 1.49) - Moder
ate
RR 1.02 (0.90 to 1.17) - Moder
ate
Adjusted mean
difference 55.3 (33.1
to 77.5), P < 0.001
Adjusted mean
difference 4.4 (2.4 to
6.3), P < 0.001
NC non-calculable, NR not reported, P probability, RR relative risk, SD standard deviation
a Hay – 15 mg/kg paracetamol + 10 mg/kg ibuprofen
b 15 mg/kg paracetamol
c 15 mg/kg + 5 mg/kg
d 15 mg/kg paracetamol
- Moder
ate
- Moder
ate
RR 1.20 (0.57 to 2.53) - Low
RR 0.33 (0.07 to 1.58) - Low