A5V4d

Antipyretic interventions
Number of studies Number of children Effect Quality
Sleep
1 (Hay et al., 2009)
Combined
27 of 51 a
Mean change temperature at 1 to 2 hours
1 hour
1 (Erlewyn-
Lajeunesse et al.,
2006)
-1.22 (0.95 to
1.50), n = 36 c
Mono Relative
(95% confidence
interval)
31 of 50 b
Mean change in temperature at > 2 to 5 hours
No data
Mean change in temperature at > 5 to 24 hours
No data
Mean change in temperature at > 24 hours
No data
Mean temperature at 1 to 2 hours
1 hour
1 (Erlewyn-
Lajeunesse et al.,
2006)
37.59°C (SD
0.61), n = 36 c
Mean temperature at > 2 to 5 hours
No data
Mean temperature at > 5 to 24 hours
1 (Hay et al., 2009) 36.6°C (SD
1.01), n = 52 a
Mean temperature at > 24 hours
1 (Hay et al., 2009) 36.0°C (SD
0.66), n = 52 a
Afebrile at 1 to 2 hours
1 (Hay et al., 2009) 47 of 52 a
Afebrile at > 2 to 5 hours
1 (Hay et al., 2009) 51 of 52 a
-0.95 (0.72 to
1.17), n = 37 d
37.98°C (SD
0.47), n = 37 d
36.4°C (SD
0.89), n = 52 b
36.2°C (SD
0.93), n = 52 b
33 of 52 b
37 of 52 b
Absolute
(95%
confidence
interval)
RR 0.85 (0.61 to 1.20) - Low
RR 0.36 (-0.10 to 0.82)
RR -0.71 (-1.18 to -
0.24)
Adjusted 0.35C (0.10
to 0.6), P = 0.028.
SMD 0.21 (-0.18 to
+0.59)
SMD -0.25 (-0.63 to
+0.14)
- Moder
ate
- Moder
ate
- Low
- Low
RR 1.42 (1.14 to 1.78) - Moder
ate
RR 1.38 (1.15 to 1.65) - Moder
ate
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