A5V4d

Number of studies Number of children Effect *
Adverse events
5 (Southey et al.,
2009; Pierce et al,
2010; Kauffman et
al., 1992; Sarrell et
al., 2006; and
Walson et al., 1989)
Discontinuation of treatment
1 (Southey et al.,
2009)
Ibuprofen Paracetamol Relative
(95% confidence
interval)
2962 of 21843 1469 of 11678 RR 1.04 (0.98 to
1.10)
5 of 257 5 of 226
RR 0.54 (0.17 to
1.71)
Antipyretic interventions
Absolute
(95%
confidence
interval)
Quality
- Very low
- Very low
AUC area under the curve, NC non-calculable, NR n ot reported, NS Not significant at P < 0.05, P probability, RR relative risk,
SD standard deviation, SMD standard mean difference
* Relative and absolute differences are calculated by the NCC technical team based on the data presented in the papers. When
this data is unavailable the authors reported figures may be used.
a Ibuprofen at 7.5 mg/kg
b Paracetamol at 10 mg/kg
c Not presented in correct format for analysis of categorical data
d 6.67 mg/kg of Ibuprofen
e Study used a non-validated scoring system
f 10.65 mg/kg of paracetamol
g 5 mg/kg of Ibuprofen
h 12.5 mg/kg of paracetamol
i At 5 mg/kg for initial temp