A5V4d

Number of studies Number of children Effect *
GBC-VAS
1 (Autret et al.,
1997)
CHEOPs discomfort
1 (Autret et al.,
1997)
Overal efficacy
1 (Figueras Nadal et
al., 2002)
Ibuprofen Paracetamol Relative
(95% confidence
interval)
27.8 (SD 29.5),
n = 114 a
2.2 (SD 0.9), n
= 114 a
64 of 94 d
Discomfort at > 5 to 24 hours
6 hours
GBC-score
1 (Autret et al.,
1997)
GBC-VAS
1 (Autret et al.,
1997)
CHEOPs discomfort
1 (Autret et al.,
1997)
Discomfort > 24 hours
Day 1
NCCPC stress test
1 (Sarrell et al.,
2006)
Day 2
NCCPC stress test
1 (Sarrell et al.,
2006)
Day 3
NCCPC stress test
1 (Sarrell et al.,
2006)
0.8 (SD 1.0),
n = 114 a
26.7 (SD 30.6),
n = 112 a
2.3 (SD 0.9),
n = 112 a
11.48 (SD
2.58),
n = 15511 g
8.83 (SD 2.67)
n = 155 g
7.96 (SD 2.71),
n = 155 g
Mean change temperature at 1 to 2 hours
1 hour
1 (Autret et al.,
1997)
-0.97°C (SD
0.58)
n=114 a
18.3 (SD 26.5),
n = 108 b
2.5 (1.0), n =
108 b
61 of 93 f
0.5 (SD 1.0),
n = 112 b
15.9 (SD 31.1),
n = 107 b
2.5 (SD 1),
n = 107 b
11.77 (SD
2.64), n=154 h
8.87 (SD 2.54)
n=154 h
7.66 (SD 2.96)
n=154 g
-0.90°C (SD
0.56)
n=114 b
Antipyretic interventions
Absolute
(95%
confidence
interval)
Quality
SMD 0.34 (0.07, 0.60) - Low
NS c - Low
RR 1.04 (0.85 to
1.27)
- Very low
NS c - Low
SMD 0.35 (+0.08 to
+0.62)
- Low
NS c - Low
SMD -0.11 (-0.33 to
+0.11)
SMD 0.02 (-0.24 to
+0.21)
SMD 0.11 (-0.12 to
+0.33)
SMD -0.12 (-0.38 to +
0.14)
- High
-
High
- High
- Low
207