A5V4d

Feverish illness in children
Number of studies Number of children Effect a
1 (Walson et al.,
1989)
1 (Walson et al.,
1989)
206
Intervention Control Relative
(95% confidence
interval)
460.9 b
0 to 6 hours – Change in temperature
1 (Wilson et al.,
1991)
1 (Wilson et al.,
1991)
Adverse events
4 (Southey et al.,
2009;
Kauffman et
al.,1992;
Walson et al.,
1989a; and
Wilson et al., 1991)
Absolute
(95%
confidence
interval)
Quality
139.0 c P < 0.05 - Low
510.8 d 139.0 c P < 0.05 - Low
7.09 (0.58) b
4.91 (0.47) d
55 of 357
11.70 (0.83) c
11.70 (0.83) c
27 of 294
RR 1.67 (1.12,
2.48)
- Low
- Low
- Low
NR n ot reported, P probability, RR relative risk, SD standard deviation, SMD standard mean difference
a Relative and absolute differences are calculated by the NCC technical team based on the data presented in the papers. When
this data is unavailable the authors reported figures may be used.
b Dose of 5 mg/kg
c Placebo
d Dose of 10 mg/kg ibuprofen
e Children aged more than 5 years included in study (Gupta up to 6; Walson up to 11; Kauffman up to 12; Wilson up to 12)
f 7.5 mg/kg ibuprofen
Table 9.4 GRADE findings for paracetamol vs. ibuprofen
Number of studies Number of children Effect *
Discomfort at 1 to 2 hours
No data
Discomfort at 2 to 5 hours
4 hours
GBC-score
1 (Autret et al.,
1997)
Ibuprofen Paracetamol Relative
(95% confidence
interval)
0.8 (SD 1), n =
116 a
0.6 (SD 0.9),
n = 113 b
Absolute
(95%
confidence
interval)
Quality
NS c - Low