A5V4d

Number of studies Number of children Effect *
Afebrile at > 2 to 5 hours
No data
Afebrile at > 5 to 24 hours
No data
Afebrile at > 24 hours
No data
Temperature area under the curve
0 to 8 hours
1 (Kauffman et al.,
1992)
1 (Walson et al.,
1989)
0 to 6 hours
1 (Wilson et al.,
1991)
Adverse events
5 (Southey et al.,
2009; Brewer et al.,
1968; Gupta et al.,
2007; Kauffman et
al., 1992; and
Walson et al., 1989)
Paracetamol Placebo Relative risk
(95% confidence
interval)
328 (-356 to
686) c
365.0 c 166.5 b
6.72
(+/- 0.58) e
23 of 385
Long-term effects of paracetamol – Asthma
1 (Beasley et al.,
2008)
- 67 (-629 to
120) b
11.70 (0.83) b
Antipyretic interventions
Absolute
(95%
confidence
interval)
Quality
P < 0.01 - Low
P < 0.05 - Low
- - Low
12 of 371 RR 1.81 (0.94 to 3.50) - Very
low
NR NR RR 1.46 (1.36 to 1.56) - Very
low
Long-term effects of paracetamol – Rhinoconjunctivitis
1 (Beasley et al.,
2008)
Long-term effects of paracetamol – Eczema
1 (Beasley et al.,
2008)
NR NR RR 1.48 (1.38 to 1.60) - Very
low
NR NR RR 1.35 (1.26 to 1.45) - Very
low
NR not reported, P probability, RR relative risk, SD standard deviation, SMD standard mean difference
* Relative and absolute differences are calculated by the NCC technical team based on the data presented in the papers. When
this data is unavailable the authors reported figures may be used.
a 15 mg/kg paracetamol repeated at 6 hours
b Placebo
c 10 mg/kg paracetamol single dose
d AUC of percentage decrease of temperature (from baseline to 98.6 ºF) vs. time
e 120 mgm/5 ml
203