A5V4d

Feverish illness in children
Table 9.2 GRADE findings for paracetamol vs. placebo
Number of studies Number of children Effect *
Quality of life at 1 to 2 hours
No data
Quality of life at > 2 to 5 hours
At 4 hours
Comfort
1 (Gupta et al.,
2007)
Activity
1 (Gupta et al.,
2007)
Alertness
1 (Gupta et al.,
2007)
Mood
1 (Gupta et al.,
2007)
Appetite
1 (Gupta et al.,
2007)
Quality of life at > 5 to 24 hours
At 6 hours
Comfort
1 (Gupta et al.,
2007)
Activity
1 (Gupta et al.,
2007)
Alertness
1 (Gupta et al.,
2007)
Mood
1 (Gupta et al.,
2007)
Appetite
1 (Gupta et al.,
2007)
200
Paracetamol Placebo Relative risk
(95% confidence
interval)
19 of 103 a 9 of 107 b
29 of 103 a 4 of 107 b
22 of 103 a 4 of 107 b
1 of 103 a 3 of 107 b
7 of 103 a 1 of 107 b
38 of 103 a 8 of 107 b
62 of 103 a 17 of 107 b
60 of 103 a 22 of 107 b
37 of 103 a 13 of 107 b
21 of 103 a 1 of 103 b
Absolute
(95%
confidence
interval)
Quality
RR 2.19 (1.04, 4.62) - Low
RR 7.53 (2.74, 20.67) - Low
RR 5.71 (2.04, 16.01) - Low
RR 3.81 (1.09, 13.26) - Low
RR 7.27 (0.91, 58.08) - Low
RR 4.93 (2.42 to
10.06)
- Low
RR 3.79 (2.38 to 6.02) - Low
RR 2.83 (1.89, 4.26) - Low
RR 2.96 (1.67 to 5.23) - Low
RR 21.00 (2.88 to
153.23)
- Low