A5V4d

Number
of
studies
Number
of
children
Sensitivity
(95%
confidence
interval)
Specificity
(95%
confidence
interval)
Positive
predictive
value
(95%
confidence
interval)
Bacteraemia, urinary tract infection. Prevalence = 10.3%
> 2 mg/l
1 (Hsiao
et al,
2006)
> 5.2 mg/l
1 (Hsiao
et al,
2006)
> 9.8 mg/l
1 (Hsiao
et al,
2006)
N = 387 100 (89 to
100)
N = 387 84 (70 to
94)
N = 387 51 (31 to
67)
29 (24 to
34)
54 (49 to
60)
80 (76 to
84)
74 (69 to
79)
50 (45 to
55)
23 (16 to
34)
Management by the paediatric specialist
Negative
predictive
value (95%
confidence
interval)
26 (22 to
31)
50 (45 to
55)
77 (72 to
81)
Positive
likelihood
ratio
(95%
confidence
interval)
1.4 (1.3 to
1.5)
1.9 (1.6 to
2.3)
2.6 (1.8 to
3.8)
Negative
likelihood
ratio
(95%
confidence
interval)
Quality
- Very
Low
0.27 (0.13 to
0.57)
0.6 (0.4 to
0.8)
Pneumonia, urinary tract infection, bacteraemia, bacterial meningitis, cellulitis, septic arthritis,
osteomyelitis, otitis media, bacterial gastroenteritis. Prevalence= 23.9%
> 20 mg/l
1
(Berger
et al,
1996)
N = 138 83.3 (70.0-
96.7
67.0 (57.7-
76.4)
43.9 (31.0-
56.7)
Occult bacteremia, bacterial meningitis, UTI. Prevalence = 0.9%
20 g/l
1
(Gomez
et al,
2010)
70 g/l
1
(Gomez
et al,
2010)
N = 1018 73.9 (53.5
to 87.5)
N = 1018 69.6 (49.1
to 89.4)
74.8 (72 to
77.5)
93.8 (92.1
to 95.1)
Occult bacteremia, UTI, Pneumonia. Prevalence = 14.3%
3 mg/dl
1 (Pratt
et al,
2007)
5 mg/dl
1 (Pratt
et al,
2007)
N = 119 88 (62 to
98)
N = 119 71 (44 to
89)
68 (58 to
76)
84 (75 to
100)
92.9 (86.8-
98.9)
3 (1 to 5) 100 (99 to
100)
9 (2 to 15) 99.3 (98.5
to 99.6)
0.31 (19 to
46)
43 (25 to
63)
97 (89 to
100)
94 (87 to
98)
2.53 (1.82-
3.50)
3.1 (2.1 to
4.5)
10.7 (6.3 to
18.0)
2.7 91.96 to
3.80)
4.5 (2.6 to
7.8)
0.25 (0.11-
0.56)
0.3 (0.1 to
1.0)
0.4 (0.1 to
0.9)
0.17 (0.05 to
0.64)
0.35 (0.17 to
0.73)
Very
Low
Very
Low
Modera
te
Very
low
Very
low
Very
Low
Very
Low
165