A5V4d

Feverish illness in children
Number
of
studies
164
Number
of
children
Sensitivity
(95%
confidence
interval)
Specificity
(95%
confidence
interval)
Positive
predictive
value
(95%
confidence
interval)
Negative
predictive
value (95%
confidence
interval)
Positive
likelihood
ratio
(95%
confidence
interval)
Negative
likelihood
ratio
(95%
confidence
interval)
Quality
Bacteremia, bacterial meningitis, sepsis, UTI, pneumonia, gastroenteritis, cellulitis. Prevalence = 23.6%
≥ 20 mg/l
1
(Olacireg
ui et al,
2009)
≥ 30 mg/l
1
(Olacireg
ui et al,
2009)
N = 347 64 (54 to
74)
N = 347 59 (48 to
70)
84 (80 to
88)
89 (85 to
93)
55 (45 to
65)
63 (52 to
74)
88 (84 to
92)
83 (87 to
91)
Bacteremia, UTI, pneumonia and bacterial meningitis. Prevalence = 16%
> 17.7 mg/l
1
(Manzan
o et al,
2011)
N = 328 94 (96 to
98)
69 (67 to
69)
Children with normal urine analysis only
> 17.7 mg/l
1
(Manzan
o et al,
2011)
N = 262 88 (54 to
98)
70 (69 to
70)
37 (34 to
39)
98 (96 to
100)
8 (5 to 9) 99 (98 to
100)
4.0 (2.9 to
5.5) b
5.4 (3.6 to
7.9) b
3.0 (2.6 to
3.2)
2.9 (2.4 to
3.5)
0.4 (0.3 to
0.6) b
0.5 (0.4 to
0.6) b
0.1 (0.0 to
0.2)
0.2 (0.1 to
0.4)
Bacterial pneumonia, bacterial meningitis, septicaemia and pyelonephritis. Prevalence = 11.1%
> 50 mg/l
1
(Thayyil
et al,
2005)
N = 72 75 (45 to
105) b
Bacteremia/sepsis. Prevalence = 0.6%
> 30 mg/l
1
(Olacireg
ui et al,
2009)
N = 347 56 (32 to
80)*
Bacteremia. Prevalence = 3.2%
≥ 40 mg/l (± IC 95%)
1 (Guen
et al,
2007)
69 (57 to
80) b
74 (69 to
79)
23 (7 to
39) b
96 (90 to
102) b
10 (4 to 16) 95 (97 to
99)
2.4 (1.4
4.1) b
2.2 (Not
reported)
0.4 (0.1 to
1.2) b
0.6 (Not
reported)
Low
Low
Low
Low
Very
Low
Very
Low
N = 215 42.8±0.37 64.8±0.07 3.8±0.22 97.2±0.06 1.21 0.88 Low