A5V4d

Table 8.2 GRADE findings for comparison of different C-reactive protein thresholds
Number
of
studies
Number
of
children
Sensitivity
(95%
confidence
interval)
Specificity
(95%
confidence
interval)
Positive
predictive
value
(95%
confidence
interval)
Management by the paediatric specialist
Negative
predictive
value (95%
confidence
interval)
Positive
likelihood
ratio
(95%
confidence
interval)
Negative
likelihood
ratio
(95%
confidence
interval)
Quality
Bacteremia, pyelonephritis, pneumonia, bacterial meningitis, bone infections, sepsis. Prevalence = 23%
20 mg/l
1
(Andreol
a et al,
2007)
40 mg/l
1
(Andreol
a et al,
2007)
80 mg/l
1
(Andreol
a et al,
2007)
N = 408 88 (80 to
94)
N = 408 71 (61 to
80)
N = 408 46 (36 to
57)
61 (55 to
66)
81 (76 to
85)
95 (92 to
97)
40 (34 to
47) a
53 (44 to
66) a
72 (60 to
83) a
95 (91 to
98) a
90 (87 to
94) a
85 (82 to
89) a
2.3 (1.9 to
2.6) b
3.8 (2.9 to
4.9) b
8.7 (5.1 to
14.1) b
Bacteraemia, pyelonephritis, lobar pulmonary condensation. Prevalence = 22.6%
40 mg/l
1
(Lacour
et al,
2001)
< 12 months of age
1
(Lacour
et al,
2001)
> 12 months of age
1
(Lacour
et al,
2001)
N = 124 89 (72 to
98)
N = 80 94 (Not
reported)
N = 80 80 (Not
reported)
75 (65 to
83)
84 (Not
reported)
59 (Not
reported)
96 (92 to
100) a
63 (Not
reported)
91 (Not
reported)
51 (37 to
65) a
98 (Not
reported)
36 (Not
reported)
3.6 (2.5 to
5.2) b
Not
reported
Not
reported
0.2 (0.1 to
0.3) b
0.4 (0.3 to
0.5) b
0.6 (0.5 to
0.7) b
0.1 (0.0 to
0.4) b
Very
Low
Very
Low
Very
Low
Low
Not reported Very
low
Not reported Very
low
Bacteremia, pyelonephritis, pneumonia, bacterial meningitis and deep abscess. Prevalence = 29%
40 mg/l
1
(Galetto-
Lacour
et al,
2003)
N = 99 79 (65 to
94)
79 (69 to
88)
61 (45 to
76)
90 (83 to
98)
3.7 (2.3 to
6.0)
0.3 (0.1 to
0.5)
Low
163