A5V4d

Feverish illness in children
Number
of
studies
162
Number
of
children
Sensitivity
(95%
confidence
interval)
Specificity
(95%
confidence
interval)
Positive
predictive
value
(95%
confidence
interval)
Negative
predictive
value (95%
confidence
interval)
Positive
likelihood
ratio
(95%
confidence
interval)
Negative
likelihood
ratio
(95%
confidence
interval)
Quality
Invasive bacterial infections: Bacterial bacterial meningitis, occult bacteremia and sepis. Prevalence = 1.7%
≥ 0.5 ng/mL
1
(Luaces-
Cubells
et al,
2012)
≥ 0.9 ng/mL
1
(Luaces-
Cubells
et al,
2012)
≥ 1 ng/mL
1
(Luaces-
Cubells
et al,
2012)
≥ 2 ng/mL
1
(Luaces-
Cubells
et al,
2012)
N = 868 0.87 (0.60
to 0.98)
N = 868 0.87 (0.60
to 0.98)
N = 868 0.73 (0.45
to 0.92)
N = 868 0.60 (0.32
to 0.84)
0.83 (0.81 to
0.86)
0.91 (0.88 to
0.92)
0.92 (0.89 to
0.93)
0.95 (0.94 to
0.97)
0.09 (0.05
to 0.14) a
0.14 (0.08
to 0.23) a
0.14 (0.07
to 0.23) a
0.19 (0.09
to 0.33) a
1.00 (0.99
to 1.00) a
1.00 (0.99
to 1.00) a
0.99 (0.99
to 1.00) a
0.99 (0.98
to 1.00) a
5.15 (4.04
to 6.66) a
9.13
(6.84 to
12.18) a
8.72 (5.97
to 12.73) a
12.80 (7.65
to 21.41) a
0.16 (0.04
to 0.58) a
0.15 (0.04
to 0.54) a
0.29 (0.13to
0.67) a
0.42 (0.23
to 0.78) a
Serious bacterial infections: Bacterial bacterial meningitis, occult bacteremia and UTI. Prevalence = 8.3%
≥ 0.2 ng/mL
1
(Woelker
et al,
2012)
≥ 0.26 ng/mL
1
(Woelker
et al,
2012)
≥ 0.3 ng/mL
1
(Woelker
et al,
2012)
N = 155 1.0 (0.72 to
1.0)
N = 155 0.92 (0.62
to 1.0)
N = 155 0.85 (0.54
to 0.97)
0.41 (0.33 to
0.49)
0.64 (0.55 to
0.72)
0.64 (0.55 to
0.72)
0.13 (0.08
to 0.22) a
0.19 (0.11
to 0.31) a
0.19 (0.10
0.32) a
1.0 (0.92 to
1.0) a
0.99 (0.93
to 1.0) a
0.98 (0.92
to 1.0) a
CI confidence interval, UTI urinary tract infection
a Estimates and confidence intervals were calculated by the NCC-WCH technical team.
b Confidence intervals were calculated by the NCC-WCH technical team.
1.69 (1.47
to 1.94) a
2.57 (1.96
to 3.37) a
2.56 (1.84
to 3.55) a
Low
Low
Low
Low
NC Very
low
0.12 (0.02
to 0.80
0.23 (0.06
to 0.83) a
Very
low
Very
low