A5V4d

Number
of
studies
Number
of
children
Sensitivity
(95%
confidence
interval)
Specificity
(95%
confidence
interval)
Positive
predictive
value
(95%
confidence
interval)
Bacteremia, UTI and bacteremia/UTI . Prevalence = 13%
0.13 ng/ml
1
(Maniaci
et al,
2008)
N = 234 97 (81 to
100)
30 (24 to
38)
17 (11 to
23)
Management by the paediatric specialist
Negative
predictive
value (95%
confidence
interval)
98 (90 to
100)
Bacteremia, UTI, bacteremia/UTI, bacterial pneumonia. Prevalence = 18%
0.12 ng/ml
1
(Maniaci
et al,
2008)
N = 234 95 (83 to
99)
26 (20 to
32)
22 (16 to
28)
96 (85 to
99)
Bacteremia, UTI, pneumonia and bacterial meningitis. Prevalence = 16%
> 0.2 ng/ml
1
(Manzan
o et al,
2011)
N = 328 85 (74 to
92)
70 (68 to
71)
Children with normal urine analysis only
> 0.2 ng/ml
1
(Manzan
o et al,
2011)
N = 262 88 (54 to
98)
71 (69 to
71)
36 (31 to
39)
96 (93 to
98)
9 (5 to 10) 99 (98 to
100)
Positive
likelihood
ratio
(95%
confidence
interval)
1.4 (1.2 to
1.6)
1.3 (1.1 to
1.4)
2.8 (2.3 to
3.2)
3.0 (1.8 to
3.3)
Negative
likelihood
ratio
(95%
confidence
interval)
0.1 (0.0 to
0.8)
0.2 (0.1 to
0.7)
0.2 (0.1 to
0.4)
0.2 (0.0 to
0.7)
Bacterial pneumonia, bacterial meningitis, septicaemia and pyelonephritis. Prevalence = 1.1%
> 500 ng/ml (> 0.5 ng/l)
1
(Thayyil
et al,
2005)
N = 72 88 (65 to
110) b
> 2000 ng/ml (> 2 ng/l)
1
(Thayyil
et al,
2005)
N = 72 50 (15 to
85) b
Bacteremia. Prevalence = 3.2%
≥ 2 ng/ml (± IC 95%)
1 (Guen
et al,
2007)
50 (38 to
62) b
86 (77 to
94) b
18 (6 to
30)2
97 (91 to
103) b
31 (6 to 56) b 93 (87 to
100) b
1.8 (1.2 to
2.5) b
3.6 (1.4 to
8.9) b
0.3 (0.0 to
1.6) b
0.6 (0.3 to
1.2) b
Quality
Low
Low
Low
Low
Very
Low
Very
Low
N = 215 57.1 ±0.37 86.4±0.05 13.8 ±0.26 98.1 ±0.06 4.19 0.49 Low
161