A5V4d

Feverish illness in children
Number
of
studies
160
Number
of
children
Fever < 8 hours
1 ng/ml
1
(Andreol
a et al,
2007)
Sensitivity
(95%
confidence
interval)
N = 45 86 (Not
reported)
Specificity
(95%
confidence
interval)
100 (Not
reported)
Positive
predictive
value
(95%
confidence
interval)
Not
reported
Negative
predictive
value (95%
confidence
interval)
Not
reported
Positive
likelihood
ratio
(95%
confidence
interval)
Not
reported
Bacteraemia, pyelonephritis, lobar pulmonary condensation. Prevalence = 22.6%
0.9 ng/ml
1
(Lacour
et al,
2001)
< 12 months of age
1
(Lacour
et al,
2001)
> 12 months of age
1
(Lacour
et al,
2001)
N = 124 93 (77 to
99)
N = 80 94 (Not
reported)
N = 44 90 (Not
reported)
78 (69 to
86)
87 (Not
reported)
62 (Not
reported)
55 (41 to
70) a
68 (Not
reported)
41 (Not
reported)
97 (94 to
101) a
98 (Not
reported)
96 (Not
reported)
4.2 (2.9 to
6.3) b
Negative
likelihood
ratio
(95%
confidence
interval)
Not
reported
0.1 (0.0 to
0.3) b
Not reported Not
reported
Not reported Not
reported
Bacteremia, pyelonephritis, pneumonia, mastoiditis and retropharyngeal abscess. Prevalence = 29%
0.5 ng/ml
1
(Galetto-
Lacour
et al,
2003)
N = 99 93 (77 to
99)
74 (62 to
84)
60 (46, 74) a 96 (91,
101) a
3.6 (2.4,
5.5) a
0.1 (0.0 to
0.4)
Quality
Bacteremia, bacterial meningitis, sepsis, UTI, pneumonia, gastroenteritis, cellulitis. Prevalence = 23.6%
≥0.5ng/ml
1
(Olacireg
ui et al,
2009)
N = 347 63 (52 to
74)
87 (83 to
91)
Bacteremia/sepsis. Prevalence = 0.6%
> 0.5 ng/ml
1
(Olacireg
ui et al,
2009)
N = 347 86 (58
to100)
93 (90 to
96)
59 (48 to
70)
35 (19 to
51)
89 (85 to
93)
99 (98
to100)
4.8 (3.5 to
7.0) b
12.3 (Not
reported)
0.4 (0.3 to
0.5) b
0.2 (Not
reported)
Very
Low
Low
Very
low
Very
low
Low
Low
Low