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Feverish illness in children reported that the risk of serious bacterial infection increased with higher heart rate centile ranges. They also showed a tendency to include a higher proportion of children with severe disease in higher heart rate centile categories. The studies were of low quality. Using changes in heart rate adjusted for temperature to detect serious illness One prospective study containing two datasets examined if age-specific centile charts of pulse rate plotted against temperature could be used to identify children with bacterial infection, and to differentiate between serious and non-serious infection. This study reported that there were no significant trends across heart rate/body temperature centiles that enabled identification of children with a severe illness. The study was of low quality. Health economic evidence statements No health economic studies were identified and no health economic evaluation was undertaken for this question. Evidence to recommendations Relative value placed on the outcomes considered The GDG stated that the overarching aim of the guideline was the early and accurate detection of serious illness in children with fever. This allows for suitable treatment to begin, which will then reduce mortality and morbidity. Consideration of clinical benefits and harms The GDG stated that, to their knowledge, all the relevant studies had been included in the review. How heart rate changes with temperature The GDG highlighted that the results of the updated review supported the conclusion of the 2007 guideline, which was that heart rate and temperature are associated with approximately a 10 bpm increase for each 1ºC increase in temperature. Using changes in heart rate alone to detect serious illness The GDG reviewed evidence on the association between unadjusted heart rate and serious illness. Based on the papers presented, the GDG concluded that there was sufficient evidence to support the inclusion of tachycardia in the traffic light table. The GDG emphasised that heart rate would vary by age and this would also have to be taken into account in any assessment, and as a result the GDG wanted to provide reference ranges for elevated heart rate. This led to a discussion on available reference ranges. The figures used for the Brent study were not available, while those used for the Craig study are shown in Table 5.62. Table 5.62 Reference ranges for elevated heart rate used in the Craig study Age (years) Recommended upper limit of normal 0 160 (WHO) 1 150 (WHO) 2 150 (WHO) 3 140 (WHO) 4 130 (Wallis) 5 120 (Wallis) Source: Wallis, Arch. Dis. Child. 2005;90;1117-1121. WHO. Common surgical problems. Ch9 Pocket Book of Hospital Care for Children. Guidelines for the management of common illnesses with limited resources. 2005, p232. The GDG members stated that in their experience one of two recognised standards were usually used to assess heart rate in children; these being the Advanced Paediatric Life Support (APLS) and Pediatric Advanced Life Support (PALS) (see Table 5.63). The GDG stated that APLS was the most 124 2013 Update

Clinical assessment of the child with fever commonly used scale in the UK, was simple to apply and closely matched the cut-offs used in the Craig study, which had shown an association between tachycardia and serious illness. Table 5.63 Normal ranges of heart rate according to Advanced Paediatric Life Support (APLS) and Pediatric Advanced Life Support (PALS) Age range (years) APLS PALS Neonate 110 – 160 85 – 205 0 – 1 110 – 160 100 – 190 1 – 2 100 – 150 100 – 190 2 – 3 95 – 140 60 – 140 3 – 5 95 – 140 60 – 140 5 – 6 80 – 120 60 – 140 APLS Advanced Paediatric Life Support, PALS Pediatric Advanced Life Support Source: Fleming et al, 2011, Normal ranges of heart rate and respiratory rate in children from birth to 18 years of age: a systematic review of observational studies, The Lancet 2011; 377: 1011–18 However, the GDG also highlighted the findings of a systematic review of normal heart rates in children (Fleming et al., 2011). This review contained data on heart rate in children from 59 studies that included 143,346 children (see Table 5.64). Table 5.64 Normal ranges of heart rate according to the Fleming study Age range 10th centile 25th centile Median 75th centile 90th centile Birth 107 116 127 138 148 0 – 3 months 123 133 143 154 164 12 – 18 months 103 112 123 132 140 18 – 24 months 98 106 116 126 135 2 – 3 years 92 100 110 119 128 3 – 4 years 86 94 104 113 123 4 – 6 years 81 89 98 108 117 (Fleming et al, 2011, Normal ranges of heart rate and respiratory rate in children from birth to 18 years of age: a systematic review of observational studies, The Lancet 2011; 377: 1011–18) 125 2013 Update

Clinical assessment of the child with fever<br />

commonly used scale in the UK, was simple to apply and closely matched the cut-offs used in the<br />

Craig study, which had shown an association between tachycardia and serious illness.<br />

Table 5.63 Normal ranges of heart rate according to Advanced Paediatric Life Support (APLS) and Pediatric<br />

Advanced Life Support (PALS)<br />

Age range (years) APLS PALS<br />

Neonate 110 – 160 85 – 205<br />

0 – 1 110 – 160 100 – 190<br />

1 – 2 100 – 150 100 – 190<br />

2 – 3 95 – 140 60 – 140<br />

3 – 5 95 – 140 60 – 140<br />

5 – 6 80 – 120 60 – 140<br />

APLS Advanced Paediatric Life Support, PALS Pediatric Advanced Life Support<br />

Source: Fleming et al, 2011, Normal ranges of heart rate and respiratory rate in children from birth to 18 years of age: a<br />

systematic review of observational studies, The Lancet 2011; 377: 1011–18<br />

However, the GDG also highlighted the findings of a systematic review of normal heart rates in<br />

children (Fleming et al., 2011). This review contained data on heart rate in children from 59 studies<br />

that included 143,346 children (see Table 5.64).<br />

Table 5.64 Normal ranges of heart rate according to the Fleming study<br />

Age range 10th centile 25th centile Median 75th centile 90th centile<br />

Birth 107 116 127 138 148<br />

0 – 3 months 123 133 143 154 164<br />

12 – 18 months 103 112 123 132 140<br />

18 – 24 months 98 106 116 126 135<br />

2 – 3 years 92 100 110 119 128<br />

3 – 4 years 86 94 104 113 123<br />

4 – 6 years 81 89 98 108 117<br />

(Fleming et al, 2011, Normal ranges of heart rate and respiratory rate in children from birth to 18 years of age: a systematic<br />

review of observational studies, The Lancet 2011; 377: 1011–18)<br />

125<br />

2013 Update

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