A5V4d

Feverish illness in children
Table 5.59 GRADE profile for the distribution of age-specific heart rate temperature data by centile group for
1,360 children presenting at a paediatric emergency department with suspected serious bacterial infection for the
detection of serious illness
Number of studies Number of
children
122
Total Children
with SBI
Effect Quality
Relative
(95% confidence
interval)
Detection of serious illness using heart rate and temperature above 97 th centile
1 (Brent et al., 2011) 135 7 OR 1.84 (95% CI 0.72 to
4.71)
Detection of serious illness using heart rate and temperature above 90 th centile
1 (Brent et al., 2011) 110 4 OR 1.19 (95% CI 0.38 to
3.73)
Detection of serious illness using heart rate and temperature above 75 th centile
1 (Brent et al., 2011) 227 11 OR 1.67 (95% CI 0.73 to
3.79)
Detection of serious illness using heart rate and temperature above 50 th centile
1 (Brent et al., 2011) 316 16 OR 1.75 (95% CI 0.83 to
3.69)
Absolute
(95% confidence
interval)
- Very
low
- Very
low
- Very
low
Detection of serious illness using heart rate and temperature below or equal to 50 th centile
1 (Brent et al., 2011) 439 13 OR 1.00 (NR) Low
CI confidence interval, OR odds ratio, NR not reported, SBI severe bacterial infection
Table 5.60 GRADE profile reporting the sensitivity, specificity and positive and negative likelihood ratios for
significant bacterial infection of cut-offs defined by heart rate and body temperature for 1360 children presenting
at a paediatric emergency department with suspected serious bacterial infection
Number of
studies
Number of
children
Sensitivity
(95%
confidence
interval)
Specificity
(95%
confidence
interval)
Positive
likelihood ratio
(95% confidence
interval)
Detection of serious illness using heart rate and temperature above 97 th centile
1 (Brent et al.,
2011)
1360 13.7 (5.7 to
26.3)
89.4 (87.5 to
91.1)
Detection of serious illness using heart rate and temperature above 90 th centile
1 (Brent et al.,
2011)
1360 21.6 (11.3 to
35.3)
80.0 (77.6 to
82.3)
Detection of serious illness using heart rate and temperature above 75 th centile
1 (Brent et al.,
2011)
1360 43.1 (29.3 to
57.8)
61.7 (58.8 to
64.5)
Negative
likelihood ratio
(95% confidence
interval)
Very
low
Quality
1.4 (0.69 to 2.7) 0.96 (0.48 to 1.9 Low
1.2 (0.76 to 1.8) 0.96 (0.63 to 1.5) Low
1.2 (0.58 to 2.3) 0.90 (0.45 to 1.8) Low