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Book of Medical Disorders in Pregnancy - Tintash

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Severe pre eclampsia at or remote from<br />

term requires delivery <strong>of</strong> the fetus<br />

(Tables 37.5 and 37.6). Expectant<br />

management under these circumstances<br />

is unusual, and requires careful patient<br />

and family counsel<strong>in</strong>g Laboratory<br />

studies utilized dur<strong>in</strong>g expectant<br />

management <strong>in</strong>clude 24 hours ur<strong>in</strong>e<br />

collections for quantitative prote<strong>in</strong> and<br />

creat<strong>in</strong><strong>in</strong>e clearance, platelet counts,<br />

liver function tests, serum fibr<strong>in</strong>ogen, PT<br />

and PTT<br />

Labor/delivery:<br />

The judicious use <strong>of</strong> fluid therapy and<br />

careful, frequent assessment <strong>of</strong> maternal<br />

vital signs is critical Cont<strong>in</strong>uous<br />

electronic fetal heart rate monitor<strong>in</strong>g is<br />

necessary to evaluate fetal status.<br />

Magnesium sulfate is the drug <strong>of</strong> choice<br />

for seizure prophylaxis (Tables 37.7 and<br />

37.8) Antihypertensive medications are<br />

employed to ma<strong>in</strong>ta<strong>in</strong> blood pressures<br />

below 160/110 mmHg (Table 37.9).<br />

Potential complications <strong>in</strong>clude oliguria,<br />

pulmonary edema, HELLP syndrome<br />

and seizures. Invasive hemodynamic<br />

monitor<strong>in</strong>g is <strong>in</strong>frequently needed. It<br />

should be employed to provide specific<br />

hemodynamic data to effect management<br />

decisions <strong>in</strong> patients who are unstable or<br />

<strong>in</strong> whom the volume status is uncerta<strong>in</strong><br />

Postnatal:<br />

Cont<strong>in</strong>ue seizure prophylaxis <strong>in</strong> preeclamptic<br />

approximately 24 h<br />

postpartum. In patients who have revere<br />

disease <strong>in</strong> the MID trimester, eclampsia<br />

or HELLP syndrome, slow resolution <strong>of</strong><br />

the disease process may dictate close<br />

monitor<strong>in</strong>g and cont<strong>in</strong>uation <strong>of</strong> seizure<br />

prophylaxis for 2-4 days Patients who<br />

still require antihypertensive medication<br />

on discharge from the hospital should be<br />

evaluated weekly. A full work-up should<br />

be <strong>in</strong>itiated for those persistently<br />

65<br />

hypertensive at/or more than 6 weeks<br />

postpartum.<br />

REFERENCES<br />

1. Menon, M.K.K.I. (61) J. Obstet. Gynec.<br />

Brit. Cwith. 68:417.<br />

2. Adams, E.M/ and Macgillivary, 1.<br />

(1961), "Long-term) Effect <strong>of</strong> Preeclampsia<br />

on Blood Pressure", Lancet,<br />

ii, 1371.<br />

3. Lean, T.N. Ratnam, S.S. and<br />

Sivasamboo, R. (1968) : J. Obstet.<br />

Gyne. Brit. Cwith. 75:856<br />

4. Macgillivray, I. (1969) "In modern<br />

Trends <strong>in</strong> Obstetrics - 4" Ed. R.J.<br />

Kellar. Butterworths,<br />

5. London - P. 244 - 245.<br />

6. Macgillivary, I, Rose, G.A. and Rowe,<br />

B. (1969), "Blood Pressure Survey <strong>in</strong><br />

<strong>Pregnancy</strong>", Cl<strong>in</strong>. Sci, 37, 395.<br />

7. Piver, M.S. (1969), "Cl<strong>in</strong>ical Evaluation<br />

<strong>of</strong> Hypertension Six Weeks<br />

postpartum", Sth. med. J., 62,559.<br />

8. Weir, R.J. Pa<strong>in</strong>t<strong>in</strong>, D.B., Robertson,<br />

J.I.S. Tree, M., Fraser, R. and Young J.<br />

(1970), "Ren<strong>in</strong> Angiotens<strong>in</strong> and<br />

Aldosterone Relationships <strong>in</strong> Normal<br />

<strong>Pregnancy</strong>", Proc. roy. Soc. Med.,<br />

63,1101.<br />

9. Bauer, G.E. (1972). "Hypertension and<br />

<strong>Pregnancy</strong>", Med. J. Aust. 2,989.<br />

10. Baird, J.T. (1972), "Parity and<br />

Hypertension", <strong>in</strong> Vital and Health<br />

Statistics, Series 11, No. 38,<br />

Wash<strong>in</strong>gton, D.C.: Public Health<br />

Service, U.S. Government Pr<strong>in</strong>t<strong>in</strong>g<br />

Office.<br />

11. Wilber, J.A. (1972), "The Management<br />

<strong>of</strong> Hypertension Dur<strong>in</strong>g <strong>Pregnancy</strong>", J.<br />

Reprod. Med. 8,53.<br />

12. Freis, E.D. (1973), The Modern<br />

Management <strong>of</strong> Hypertension.<br />

Wash<strong>in</strong>gton, D.C.: Veterans<br />

Adm<strong>in</strong>istration.

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