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Book of Medical Disorders in Pregnancy - Tintash

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differentiat<strong>in</strong>g between chronic<br />

hypertension and pregnancy <strong>in</strong>-duced<br />

hypertension when a patient becomes<br />

hypertensive <strong>in</strong> the early third trimester.<br />

Patients, who require less than 7 mg <strong>of</strong><br />

angiotens<strong>in</strong> II per kilogram <strong>of</strong> body<br />

weight per m<strong>in</strong>ute to elicit a pressure<br />

response at this time, can be diagnosed<br />

as case <strong>of</strong> preeclampsia. The student<br />

must be cautioned here that <strong>in</strong> normal<br />

cl<strong>in</strong>ical practice such tests can not be<br />

done, therefore no attempt should be<br />

made to perform this test. Such cases<br />

should be referred to a referral centre<br />

equipped with these diagnostic facilities.<br />

Chronic hypertension with<br />

superimposed pre eclampsia:<br />

Chronic hypertension with superimposed<br />

pre-eclampsia is the result <strong>of</strong> acute aggravation<br />

<strong>of</strong> the already exist<strong>in</strong>g underly<strong>in</strong>g<br />

hypertension, with the rapid development<br />

<strong>of</strong> edema and prote<strong>in</strong>uria. The<br />

funduscopic f<strong>in</strong>d<strong>in</strong>gs show<strong>in</strong>g re-t<strong>in</strong>al<br />

sheen, hemorrhages, and exudates may<br />

become more prom<strong>in</strong>ent. There is <strong>of</strong>ten<br />

a quick progression to eclampsia, which<br />

may develop before the 30th week <strong>of</strong><br />

gestation. Strict diagnostic criteria are<br />

sometimes difficult to establish but<br />

depend on the follow<strong>in</strong>g.<br />

When documented evidence is available<br />

that the patient had chronic hypertension<br />

along with the evidence <strong>of</strong> a<br />

superimposed acute process, as<br />

demonstrated by elevation <strong>of</strong> systolic<br />

blood pressure by 30 mm Hg or diastolic<br />

blood pressure by 15 to 20 mm Hg<br />

above the base l<strong>in</strong>e on two occasions at<br />

least 6-hours apart. Prote<strong>in</strong>uria and or<br />

edema as observed <strong>in</strong> women with preeclampsia<br />

are also present. The<br />

development <strong>of</strong> any one <strong>of</strong> the three<br />

signs <strong>of</strong> superimposed preeclampsia, that<br />

53<br />

is, worsen<strong>in</strong>g hyper-tension, prote<strong>in</strong>uria,<br />

or edema, may al-one if severe enough,<br />

justify the diagnosis <strong>of</strong> superimposed<br />

preeclampsia. However, the diagnosis<br />

should re-quire the presence <strong>of</strong><br />

accelerated hyper-tension accompanied<br />

by at least one <strong>of</strong> the two other signs.<br />

If the gravida with chronic hypertension<br />

requires less than 7 mg/kg/m<strong>in</strong>ute <strong>of</strong><br />

angiotens<strong>in</strong> II to elicit a 20 mm Hg<br />

<strong>in</strong>crease <strong>in</strong> diastolic blood pressure, it is<br />

likely that she has superimposed preeclampsia.<br />

Normal<br />

blood<br />

flow<br />

Carotid<br />

Arteries<br />

Bra<strong>in</strong><br />

Decreased<br />

Blood flow<br />

Fig4.6: Shows bra<strong>in</strong> vessels exposed.<br />

Latent or transient hypertension:<br />

The category <strong>of</strong> 'Intent or transient<br />

hypertension <strong>in</strong>cludes only those patients<br />

whose transient elevations <strong>of</strong> blood pressure<br />

are observed dur<strong>in</strong>g labor or <strong>in</strong> the<br />

early puerperium.<br />

Their illnesses may range widely from<br />

mild preeclampsia to latent or early<br />

vascular hypertension.<br />

Management <strong>of</strong> pregnancy <strong>in</strong>duced<br />

hypertension:<br />

The management <strong>in</strong>cludes prevention<br />

and therapeutic treatment.

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