Book of Medical Disorders in Pregnancy - Tintash
Book of Medical Disorders in Pregnancy - Tintash
Book of Medical Disorders in Pregnancy - Tintash
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3.19, 1.29 and 1.30, respectively [10].<br />
However, this may be an artifactual<br />
result, s<strong>in</strong>ce radiographic studies <strong>in</strong> the<br />
first trimester may have <strong>in</strong>cluded a<br />
disproportionately high fraction <strong>of</strong> high<br />
dose non-obstetric studies such as IVPs<br />
and barium enemas. Also, experimental<br />
work <strong>in</strong> dogs suggests exposure later <strong>in</strong><br />
gestation is more carc<strong>in</strong>ogenic.<br />
None-theless, the possibility <strong>of</strong> premalignant<br />
change <strong>in</strong> the first trimester<br />
rema<strong>in</strong>s, lead<strong>in</strong>g the NRPB to assume<br />
that some risk exists after irradiation <strong>in</strong><br />
the first weeks <strong>of</strong> pregnancy. Assum<strong>in</strong>g<br />
a rela-tively high fetal dose estimate <strong>of</strong> 5<br />
rads for a pelvic CT dur<strong>in</strong>g pregnancy,<br />
the relative risk <strong>of</strong> fatal childhood cancer<br />
may be doubled. This relative risk may<br />
appear substantial, but it should be<br />
remembered that the basel<strong>in</strong>e risk is very<br />
low, so that the odds <strong>of</strong> dy<strong>in</strong>g <strong>of</strong><br />
childhood cancer go from 1 <strong>in</strong> 2000<br />
(basel<strong>in</strong>e) to 2 <strong>in</strong> 2000 (after 5 rads). To<br />
assist with patient counsel<strong>in</strong>g, some<br />
practical risk comparisons may be<br />
helpful. The excess risk (<strong>of</strong> 1 <strong>in</strong> 2000) is<br />
equivalent to driv<strong>in</strong>g 20,000 miles <strong>in</strong> a<br />
car or liv<strong>in</strong>g <strong>in</strong> New York City for 3<br />
years. It should also be noted that the<br />
guidel<strong>in</strong>es <strong>of</strong> the American College <strong>of</strong><br />
Obstetricians and Gynecologists are<br />
superficial <strong>in</strong> their discussion <strong>of</strong> the<br />
carc<strong>in</strong>ogenic risk <strong>of</strong> radiation dur<strong>in</strong>g<br />
pregnancy, describ<strong>in</strong>g it as "very small"<br />
and conclud<strong>in</strong>g "abortion should not be<br />
recommended". The ACOG guidel<strong>in</strong>es<br />
do not <strong>in</strong>dicate what <strong>in</strong>formation or risk<br />
estimates should be provided dur<strong>in</strong>g<br />
parental counsel<strong>in</strong>g, if any. CT <strong>of</strong> the<br />
fetus should be avoided <strong>in</strong> all trimesters<br />
<strong>of</strong> pregnancy, because it may cause up to<br />
a doubl<strong>in</strong>g <strong>of</strong> the risk <strong>of</strong> fatal childhood<br />
cancer.<br />
219<br />
Avoid<strong>in</strong>g exposure <strong>in</strong> pregnancy: No<br />
law or pr<strong>of</strong>essional standard requires<br />
that radiologists determ<strong>in</strong>e <strong>in</strong> advance<br />
whether a patient <strong>of</strong> childbear<strong>in</strong>g age is<br />
pregnant. However, it is clearly good<br />
practice to implement the follow<strong>in</strong>g guidel<strong>in</strong>es:<br />
Signs should be prom<strong>in</strong>ently displayed<br />
<strong>in</strong> all radiology departments ask<strong>in</strong>g each<br />
patient to notify a technologist or physician<br />
if she is, or th<strong>in</strong>ks she could be,<br />
pregnant. All technologists should ask<br />
women <strong>of</strong> childbear<strong>in</strong>g age if they might<br />
be pregnant prior to perform<strong>in</strong>g a<br />
radiologic procedure. Radiology requisition<br />
forms filled out by referr<strong>in</strong>g physicians<br />
should <strong>in</strong>clude a section deal<strong>in</strong>g<br />
with the possibility <strong>of</strong> pregnancy. No<br />
radiological procedure <strong>in</strong>volv<strong>in</strong>g exposure<br />
to the pelvis should be undertaken<br />
<strong>in</strong> a patient who declares she may<br />
be pregnant without consultation with a<br />
radiologist. The radiologist should<br />
discuss risks and benefits with the<br />
patient, and determ<strong>in</strong>e if it is appropriate<br />
to proceed, perform an alternative<br />
procedure, or delay the study to allow<br />
performance <strong>of</strong> a pregnancy test. It<br />
should be noted that current<br />
recommendations do not recognize a<br />
safe period dur<strong>in</strong>g the menstrual cycle,<br />
and so the concept <strong>of</strong> the "ten day rule"<br />
is obsolete.<br />
A patient who th<strong>in</strong>ks she may be<br />
pregnant should be discussed with the<br />
referr<strong>in</strong>g physician, <strong>in</strong> order to determ<strong>in</strong>e<br />
the appropriate course <strong>of</strong> action (e.g.,<br />
reschedul<strong>in</strong>g after pre-gnancy test<strong>in</strong>g,<br />
proceed<strong>in</strong>g with the test after counsel<strong>in</strong>g,<br />
or chang<strong>in</strong>g to another modality). It is<br />
the responsibility <strong>of</strong> the patient to<br />
disclose any possibility <strong>of</strong> pregnancy,<br />
although appropriate sign-age and<br />
question<strong>in</strong>g <strong>of</strong> all women <strong>of</strong>