Download (8Mb) - Etheses - Saurashtra University

(s, 1H), 3.16 (s, 3H), 1.80 (m, 2H), 1.53 (m, 12H). 13 C NMR (75.5 MHz, CDCl3) δ =
151.5, 138.8, 136.2, 127.7 (x 3), 124.0 (x 2), 105.1, 53.7, 44.6, 32.3 (x 2), 27.2 (x 2),
25.2, 23.4 ( x 2). HRMS EI C18H25N3O2S, calcd 344.1667. , found : 344.1644.
4-(2-(2-Methoxyethylamino)-1H-imidazole-5-yl)benzonitrile(BS-139)
O
N
H
N
N
H
N
Yield 85 %. 1 H NMR (300 MHz, DMSO d6) δ = 10.6 (br, 1H), 7.7 (m 4H), 7.3 (s 1H),
5.8 (s 1H), 3.5 (t 2H), 3.4 (m 2H), 3.2 (s 3H). 13 C NMR (300 MHz, DMSO d6) δ
=151.3, 140.1, 134.2, 132.2(x 2), 123.8, 119.5, 110.8, 106.4, 104.1, 70.9, 57.9, 54.8,
43.3. HRMS EI C13H14N4O, calcd 242.1168 , found : 242.1167.
5-(4-Methoxyphenyl)-N-octyl-1H-imidazol-2-amine (BS-258 )
C 8H 17
N
H
N
N
H
O
Yield : 78 %. 1 H NMR (300 MHz, DMSO-d6): δ = 10.91 (br s, 1H), 7.51 (d, J = 8.57
Hz, 2H), 6.95 (s, 1H), 6.87 (d, J = 8.75 Hz, 2H), 6.05 (m, 1H), 3.74 (s, 3H), 3.16 (m,
2H), 1.51 (m, 2H), 1.28 (m, 10H), 0.85 (t, J = 6.75 Hz, 3H). 13 C NMR (75.5 MHz,
CDCl3): δ =149.2, 131.1, 129.5, 129.3 (×2), 128.8 (×2), 128.2, 123.4, 43.1, 31.6, 29.5,
29.0, 28.9, 26.4, 22.2, 14.0. HRMS (EI): C18H27N3O, calcd 301.2154, found:
301.2142.
5-(4-Fluorophenyl)-N-octyl-1H-imidazol-2-amine (BS-259)
C 8H 17
N
H
N
N
H
F
Yield : 69% . 1 H NMR (300 MHz, DMSO-d6): δ = 10.44 (br s, 1H), 7.61 (t, J = 5.85
Hz, 2H), 7.08 (t, J = 8.78 Hz, 2H), 6.99 (s, 1H), 5.67 (t, J = 6.03 Hz, 1H), 3.10 (m,
2H), 1.51 (m, 2H), 1.25 (m, 10H), 0.83 (m, 3H). 13 C NMR (75.5 MHz, CDCl3): δ
=163.8, 160.5, 148.7, 130.2, 128.4, 127.0, 122.9, 115.5, 104.7, 43.0, 31.6, 29.5, 29.0,
28.9, 26.4, 22.5, 14.0. HRMS (EI): C17H24FN3, calcd 289.1954, found:. 289.1964.
5-(3,4-Dichlorophenyl)-N-octyl-1H-imidazol-2-amine (BS-260)
C 8H 17
N
H
N
N
H
Cl
Cl