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C3H7 HN
N
N
H
Cl
Cl
Yield : 70 %. 1 H NMR (300 MHz, DMSO-d6) δ = 10.55 (br, 1H), 7.82 (s, 1H), 7.58
(s, 1H), 7.50 (d, J = 8.2 Hz, 1H), 7.22 (s, 1H), 5.83 (t, J = 6.0 Hz, 1H), 3.10 (q, J = 8.2
Hz, 2H), 1.54 (m, 2H), 0.90 (t, J = 7.35 Hz, 3H). 13 C NMR (75.5 MHz, DMSO-d6) δ
=151.6, 130.9 (x 2), 130.3 (x 2), 126.3, 124.6, 123.4, 104.2, 44.7, 22.6, 11.4. HRMS
EI C12H13Cl2N3, calcd 269.0487, found : 269.0480.
N-Cyclohexyl-5-(4-(methylsulfonyl)phenyl)-1H-imidazol-2-amine (BS-141)
HN
N
N
H
S O
O
Yield : 43 %. 1 H NMR (300 MHz, DMSO-d6) δ = 10.54 (br, 1H), 7.83-7.76 (m, 4H),
7.31 (s, 1H), 5.75 (d, J = 8.4 Hz, 1H), 3.16 (s, 3H), 2.49 (s, 1H), 1.90 (s, 2H), 1.70 (m,
2H), 1.20 (m, 6H). 13 C NMR (75.5 MHz, DMSO-d6) δ =151.1, 140.1, 136.1, 127.2(x
4), 123.4 (x 2), 104.2, 51.1, 43.7, 33.0(x 2), 25.4, 24.6(x 2). HRMS EI C16H21N3O2S,
calcd 319.1354. , found : 319.1337.
5-(4-Chlorophenyl)-N-octyl-1H-imidazol-2-amine (BS-143)
C8H17 HN
N
N
H
Cl
Yield : 43%. 1 H NMR (300 MHz, DMSO-d6) δ = 10.43 (br, 1H), 7.63 (d, J = 8.3 Hz,
2H), 7.31 (d, J = 8.4 Hz, 2H), 7.09 (s, 1H), 5.71 (t, J = 4.9 Hz, 1H), 3.12 (m, 2H),
1.48-1.51 (m, 2H), 1.25 (m, 10H), 0.85 (t, J = 4.2 Hz, 3H). 13 C NMR (75.5 MHz,
DMSO-d6) δ =151.5, 128.8 (x 2), 128.1 (x 3), 124.9 (x 2), 100.7, 42.9, 31.2, 29.4,
28.8, 28.7, 26.4, 22.0, 13.9. HRMS EI C17H24ClN3, calcd 305.1659, found : 305.1646.
5-(4-Chlorophenyl)-N-pentyl-1H-imidazol-2-amine (BS-146)
C5H11 HN
N
N
H
Cl