Yield: 88%. 1 H NMR (300 MHz, CDCl3): δ = 8.27 (d, J = 4.77 Hz, 2H), 6.50 (t, J = 4.8 Hz, 1H), 5.07 (br s, 1H), 3.38 (m, 2H), 1.60 (m, 2H), 1.25 (m, 22H), 0.88 (t, J = 6.9, 3H). 13 C NMR (75.5 MHz, CDCl3): δ = 162.4, 158.0 (×2), 110.2, 41.5, 31.9, 29.6 (×7), 29.3 (×2), 26.9, 22.7, 14.1. HRMS (EI): C18H33N3, calcd 291.4747, found: 291.4723. 1-Heptyl-2-hydroxy-2-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide amine (BS-049) N Br N N C 7H 15 OH Yield: 75 %. 1 H NMR (300 MHz, CDCl3): δ = 9.03 (m, 1H), 8.85 (m, 1H), 7.80 (s, 1H), 7.77 (m, 2H), 7.49 (m, 3H), 7.31 (m, 1H), 4.82 (s, 2H). 3.17 (m, 2H), 1.36 (m, 2H), 1.09 (m, 8H), 0.80 (t, J = 6.84 Hz, 3H). 2-Hydroxy-1-octyl-2-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide (BS-052) N Br N N C 8H 17 OH Yield: 73 %. 1 H NMR (300 MHz, CDCl3): δ = 9.03 (m, 1H), 8.86 (m, 1H), 7.80 (s, 1H), 7.75 (m, 2H), 7.47 (m, 3H), 7.31 (t, J = 5.49 Hz, 1H), 4.83 (s, 2H). 3.17 (m, 2H), 1.36 (m, 2H), 1.09 (m, 10H), 0.83 (t, J = 6.72 Hz, 3H). 1-Decyl-2-hydroxy-2-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide (BS-055) N Br N N C 10H 21 OH
Yield: 78 %. 1 H NMR (300 MHz, CDCl3): δ = 9.03 (d, J = 4.62 Hz, 1H), 8.87 (d, J = 6.18 Hz, 1H), 7.81 (s, 1H), 7.74 (m, 2H), 7.47 (m, 3H), 7.31 (m, 1H), 4.83 (s, 2H). 3.17 (m, 2H), 1.09 (m, 16H), 0.85 (t, J = 6.51 Hz, 3H). 13 C NMR (75.5 MHz, CDCl3): δ =167.5, 154.5, 148.2, 138.2, 129.2, 128.3 (×2), 126.9 (×2), 111.1, 90.6, 62.6, 40.7, 31.2, 28.7, 28.6, 28.5, 28.2, 27.3, 25.8, 22.0, 13.9. 1-Hexyl-2-hydroxy-2-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide (BS-058) N Br N N C 6H 13 OH Yield: 80 %. 1 H NMR (300 MHz, CDCl3): δ = 9.03 (m, 1H), 8.87 (m, 1H), 7.81 (s, 1H), 7.74 (m, 2H), 7.47 (m, 3H), 7.31 (m 1H), 4.83 (s, 2H). 3.17 (m, 2H), 1.34 (m, 2H), 1.09 (m, 6H), 0.78 (t, J = 6.48 Hz, 3H). 2-Hydroxy-1-nonyl-2-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide (BS-061) N Br N N C 9H 19 OH Yield: 75 %. 1 H NMR (300 MHz, CDCl3): δ = 9.03 (m, 1H), 8.87 (m, 1H), 7.80 (s, 1H), 7.74 (m, 2H), 7.47 (m, 3H), 7.31 (t, J = 6.21 Hz, 1H), 4.83 (s, 2H). 3.17 (m, 2H), 1.09 (m, 14H), 0.84 (t, J = 6.63 Hz, 3H). 13 C NMR (75.5 MHz, CDCl3): δ =167.5, 154.5, 148.2, 138.2, 129.2, 128.3 (×2), 126.9 (×2), 111.1, 90.6, 62.6, 40.7, 31.1, 28.5, 28.4, 28.2, 27.3, 25.8, 22.0, 13.9. 2-Hydroxy-2-phenyl-1-undecyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide (BS-064) N Br N N C 11H 23 OH
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Saurashtra University Re - Accredit
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JANUARY-2011 Statement under O. Ph.
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Acknowledgment This thesis arose in
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since I was a child. My Mother Hans
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CHAPTER - 2 Microwave Assisted Synt
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5.5 Results and discussion 156 5.6
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Ms Mesyl MW Microwave NBS N-bromosu
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1. Microwave Assisted Organic Synth
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1.4 Heating Mechanism In microwave
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1.5. Effects of solvents Every solv
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1.7 Application of microwave in org
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aromatic amines, Lancini’s group
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1.9 2-Aminoimidazole Alkaloids The
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5-(4-Chlorophenyl)-1-cyclobutyl-1H-
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Yield: 66%. 1 H NMR (300 MHz, CDCl3
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3.10 Representative NMR spectra 3.1
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3.11 References [1] (a) Alvi K. A,
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Copper Catalyzed Microwave Assisted
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4.1 Introduction There are only a f
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(Table-1, No- 6). Next reaction tem
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No. Product, Yield b (%) No. Produc
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4.4 Possible Mechanism Regarding th
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4.7 Experimental protocols 4.7.1 Ge
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Yield: 69 %. 1 H NMR (300 MHz, CDCl
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1-(3-Azidopropyl)-2-(3,4-dichloroph
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Yield: 84 %. 1 H NMR (300 MHz, DMSO
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Yield: 80 %. 1 H NMR (300 MHz, DMSO
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Yield: 83 %. 1 H NMR (300 MHz, DMSO
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1H), 1.66 (m, 6H), 1.70 (m, 2H). 13
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5.48 Hz, 2H), 3.59 (m, 2H), 3.16 (d
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4.10 References [1] For a general r
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Crystal and Molecular Structure Ana
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5.1 Introduction The membrane efflu
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oscillation range of 5˚ and proces
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C12-C13 1.372(4) C32-C37 1.390(3) C
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Fig.-3: Packing of the molecules wh
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1 H NMR (400 MHz CDCl3): δ = 7.57-
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5.9.2 13 C spectra of bs-DP-7
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SUMMARY The work represented in the
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CONFERENCES/SEMINARS/WORKSHOPS ATTE
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PUBLICATIONS [1] One-Pot Microwave-
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Scheme 2 Competitive formation of 1
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Table 2 continued 9 10 11 12 N hydr
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8. Colson G, Raboult L, Lavelle F,