Download (8Mb) - Etheses - Saurashtra University

More documents

Recommendations

Info

Yield: 88%. 1 H NMR (300 MHz, CDCl3): δ = 8.27 (d, J = 4.77 Hz, 2H), 6.50 (t, J = 4.8 Hz, 1H), 5.07 (br s, 1H), 3.38 (m, 2H), 1.60 (m, 2H), 1.25 (m, 22H), 0.88 (t, J = 6.9, 3H). 13 C NMR (75.5 MHz, CDCl3): δ = 162.4, 158.0 (×2), 110.2, 41.5, 31.9, 29.6 (×7), 29.3 (×2), 26.9, 22.7, 14.1. HRMS (EI): C18H33N3, calcd 291.4747, found: 291.4723. 1-Heptyl-2-hydroxy-2-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide amine (BS-049) N Br N N C 7H 15 OH Yield: 75 %. 1 H NMR (300 MHz, CDCl3): δ = 9.03 (m, 1H), 8.85 (m, 1H), 7.80 (s, 1H), 7.77 (m, 2H), 7.49 (m, 3H), 7.31 (m, 1H), 4.82 (s, 2H). 3.17 (m, 2H), 1.36 (m, 2H), 1.09 (m, 8H), 0.80 (t, J = 6.84 Hz, 3H). 2-Hydroxy-1-octyl-2-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide (BS-052) N Br N N C 8H 17 OH Yield: 73 %. 1 H NMR (300 MHz, CDCl3): δ = 9.03 (m, 1H), 8.86 (m, 1H), 7.80 (s, 1H), 7.75 (m, 2H), 7.47 (m, 3H), 7.31 (t, J = 5.49 Hz, 1H), 4.83 (s, 2H). 3.17 (m, 2H), 1.36 (m, 2H), 1.09 (m, 10H), 0.83 (t, J = 6.72 Hz, 3H). 1-Decyl-2-hydroxy-2-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide (BS-055) N Br N N C 10H 21 OH
Yield: 78 %. 1 H NMR (300 MHz, CDCl3): δ = 9.03 (d, J = 4.62 Hz, 1H), 8.87 (d, J = 6.18 Hz, 1H), 7.81 (s, 1H), 7.74 (m, 2H), 7.47 (m, 3H), 7.31 (m, 1H), 4.83 (s, 2H). 3.17 (m, 2H), 1.09 (m, 16H), 0.85 (t, J = 6.51 Hz, 3H). 13 C NMR (75.5 MHz, CDCl3): δ =167.5, 154.5, 148.2, 138.2, 129.2, 128.3 (×2), 126.9 (×2), 111.1, 90.6, 62.6, 40.7, 31.2, 28.7, 28.6, 28.5, 28.2, 27.3, 25.8, 22.0, 13.9. 1-Hexyl-2-hydroxy-2-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide (BS-058) N Br N N C 6H 13 OH Yield: 80 %. 1 H NMR (300 MHz, CDCl3): δ = 9.03 (m, 1H), 8.87 (m, 1H), 7.81 (s, 1H), 7.74 (m, 2H), 7.47 (m, 3H), 7.31 (m 1H), 4.83 (s, 2H). 3.17 (m, 2H), 1.34 (m, 2H), 1.09 (m, 6H), 0.78 (t, J = 6.48 Hz, 3H). 2-Hydroxy-1-nonyl-2-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide (BS-061) N Br N N C 9H 19 OH Yield: 75 %. 1 H NMR (300 MHz, CDCl3): δ = 9.03 (m, 1H), 8.87 (m, 1H), 7.80 (s, 1H), 7.74 (m, 2H), 7.47 (m, 3H), 7.31 (t, J = 6.21 Hz, 1H), 4.83 (s, 2H). 3.17 (m, 2H), 1.09 (m, 14H), 0.84 (t, J = 6.63 Hz, 3H). 13 C NMR (75.5 MHz, CDCl3): δ =167.5, 154.5, 148.2, 138.2, 129.2, 128.3 (×2), 126.9 (×2), 111.1, 90.6, 62.6, 40.7, 31.1, 28.5, 28.4, 28.2, 27.3, 25.8, 22.0, 13.9. 2-Hydroxy-2-phenyl-1-undecyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide (BS-064) N Br N N C 11H 23 OH
Page 1 and 2:
Saurashtra University Re - Accredit
Page 3:
JANUARY-2011 Statement under O. Ph.
Page 7 and 8:
Acknowledgment This thesis arose in
Page 9 and 10:
since I was a child. My Mother Hans
Page 11 and 12:
CHAPTER - 2 Microwave Assisted Synt
Page 13 and 14:
5.5 Results and discussion 156 5.6
Page 15 and 16:
Ms Mesyl MW Microwave NBS N-bromosu
Page 17 and 18:
1. Microwave Assisted Organic Synth
Page 19 and 20:
1.4 Heating Mechanism In microwave
Page 21 and 22:
1.5. Effects of solvents Every solv
Page 23 and 24:
1.7 Application of microwave in org
Page 25 and 26:
aromatic amines, Lancini’s group
Page 27 and 28:
1.9 2-Aminoimidazole Alkaloids The
Page 29 and 30: Recently group of Erik 83 described
Page 31 and 32: 1.10 Methods for the preparation of
Page 33 and 34: R 1 O X R 2 NH 2 H 2N NAc R 1 HN R
Page 35 and 36: this manifold, was reported in 1925
Page 37 and 38: Another route to 4(5)-acyl-2-amino-
Page 39 and 40: this series of compounds against th
Page 41 and 42: documented. Extra care is needed be
Page 43 and 44: Very recently the research group of
Page 45 and 46: OH a,b O N H2N N Boc N 3 H N R N N
Page 47 and 48: 1.12.2 Biofilm Growth Cycle 1) Plan
Page 49 and 50: can survive both the onslaught of a
Page 51 and 52: [26] Leadbeater, N. E. (2004) Chemi
Page 53 and 54: [86] Kreutzberger, A. (1962) J. Org
Page 55 and 56: Microwave Assisted Synthesis & Stru
Page 57 and 58: 2.1 Introduction As described in ch
Page 59 and 60: 2.3 Proposed Mechanism: Regarding t
Page 61 and 62: No. 12 60 120 traces 84 a All react
Page 63 and 64: the development of biofilm related
Page 65 and 66: In first instance, a series of 2-hy
Page 67 and 68: Br N N N R 1 OH Br N N N R 1 OH Fig
Page 69 and 70: do have a very strong effect agains
Page 71 and 72: 2.6 Conclusion In the present study
Page 73 and 74: 2.8 Biological assays 2.8.1 Static
Page 75 and 76: 2.9 Experimental protocol: 2.9.1 Ge
Page 77 and 78: temperature of 80 °C and a maximum
Page 79: 29.5,29.4, 29.2, 27.0, 22.6, 14.1.
Page 83 and 84: N Br N N C 14H 29 OH Yield: 72 %. 1
Page 85 and 86: (75.5 MHz, CDCl3): δ = 167.7, 154.
Page 87 and 88: N Br N N C 14H 29 OH Cl Yield: 90 %
Page 89 and 90: 2-(3,4-Dichlorophenyl)-2-hydroxy-1-
Page 91 and 92: N Br N N C 8H 17 OH NO 2 Yield: 49
Page 93 and 94: C3H7 HN N N H Cl Cl Yield : 70 %. 1
Page 95 and 96: (s, 1H), 3.16 (s, 3H), 1.80 (m, 2H)
Page 97 and 98: 5-(4’-Nitrobiphenyl-4-yl)-N-octyl
Page 99 and 100: 2.11 Representative NMR spectra 2.1
Page 101 and 102: 2.11.3 10.4329 0.7429 151.5720 10.0
Page 103 and 104: [21] Matz C, McDougald D, Moreno A.
Page 105 and 106: Chapter-3 Structure Activity Relati
Page 107 and 108: imidazoles, where the addition of a
Page 109 and 110: 3.4 Result and Discussion It was fo
Page 111 and 112: No. H 2N Compound Code N N C8H17 R1
Page 113 and 114: medium used in the set-up to monito
Page 115 and 116: H 2N N N N H2N N R R Figure-1 Effec
Page 117 and 118: 3.5.3 Cyclo-alkyl 2-aminoimidazoles
Page 119 and 120: 3.6. Conclusion In the present stud
Page 121 and 122: 3.8. Experimental protocols 3.8.1 G
Page 123 and 124: 122.6, 54.6, 33.3(×2), 27.3 (×2),
Page 125 and 126: Yield: 52 %. 1 H NMR (300 MHz, CDCl
Page 127 and 128: 5-(4-Chlorophenyl)-1-cyclooctyl-1H-
Page 129 and 130: Yield: 50 %. Mp: 76-78 ° C. 1 H NM
Page 131 and 132:
5-(4-Chlorophenyl)-1-cyclobutyl-1H-
Page 133 and 134:
Yield: 66%. 1 H NMR (300 MHz, CDCl3
Page 135 and 136:
3.10 Representative NMR spectra 3.1
Page 137 and 138:
3.11 References [1] (a) Alvi K. A,
Page 139 and 140:
Copper Catalyzed Microwave Assisted
Page 141 and 142:
4.1 Introduction There are only a f
Page 143 and 144:
(Table-1, No- 6). Next reaction tem
Page 145 and 146:
No. Product, Yield b (%) No. Produc
Page 147 and 148:
4.4 Possible Mechanism Regarding th
Page 149 and 150:
4.7 Experimental protocols 4.7.1 Ge
Page 151 and 152:
Yield: 69 %. 1 H NMR (300 MHz, CDCl
Page 153 and 154:
1-(3-Azidopropyl)-2-(3,4-dichloroph
Page 155 and 156:
Yield: 84 %. 1 H NMR (300 MHz, DMSO
Page 157 and 158:
Page 159 and 160:
Page 161 and 162:
1H), 1.66 (m, 6H), 1.70 (m, 2H). 13
Page 163 and 164:
5.48 Hz, 2H), 3.59 (m, 2H), 3.16 (d
Page 165 and 166:
4.10 References [1] For a general r
Page 167 and 168:
Crystal and Molecular Structure Ana
Page 169 and 170:
5.1 Introduction The membrane efflu
Page 171 and 172:
oscillation range of 5˚ and proces
Page 173 and 174:
C12-C13 1.372(4) C32-C37 1.390(3) C
Page 175 and 176:
Fig.-3: Packing of the molecules wh
Page 177 and 178:
1 H NMR (400 MHz CDCl3): δ = 7.57-
Page 179 and 180:
5.9.2 13 C spectra of bs-DP-7
Page 181 and 182:
SUMMARY The work represented in the
Page 183 and 184:
CONFERENCES/SEMINARS/WORKSHOPS ATTE
Page 185:
PUBLICATIONS [1] One-Pot Microwave-
Page 200 and 201:
Scheme 2 Competitive formation of 1
Page 202 and 203:
Table 2 continued 9 10 11 12 N hydr
Page 204:
8. Colson G, Raboult L, Lavelle F,
show all

Download (8Mb) - Etheses - Saurashtra University

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?