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Many thanks go in particular to Dr.Denis Ermolet’v. I am much indebted to Denis for his valuable advice in scientific discussion and synthetic part of this thesis. To the role model for hard workers in the lab, Dr. Vaibhav Mehta, I would like to thank him for many reasons. I would also acknowledge Sachin, Rupesh, Ripula, Dipak, Punit, Bari, Jigo, Nigam, Nick, Prof. BK, and Claudia (Lab Mummy) for their advice and their willingness to share their bright thoughts with me, which was very fruitful for shaping up my ideas and research. Thanks to each and every members of LOMAC. Collective and individual acknowledgments are also owed to my colleagues at <strong>Saurashtra</strong> <strong>University</strong> whose presence somehow perpetually refreshed, helpful, and memorable. Many thanks go in particular to Vaibhav, Bunty, Ravi, Sailesh, Shrey, Dhiru, Abhay, Bapu, Nilay, Manisha, Harshad, Ronny, Mrunal, Rakshit, Ashish, Priti, Fatema, Ketaki, Dilip, Pratik, Vishwa and Paresh. I was extraordinarily fortunate in having Rahul, Matre, Jigo, Bharat, Suresh, Pankaj, Atul, Raju, Naval, Naimish, Dodia, Ghetiya Satish and Mahesh as my friends. Thank s to all dear. To Prashant Shah, thank for giving me the opportunity to work on your O2h in Ahmedabad. To Cnp, Tusharbhai, Jigo, Pradip, Hemal, Nileshwari, Shabu, PP, Hiral, Tejas, Pareshbhai and Vikas thank for your technical assistances and fun during the work we had in O2h. It is also a pleasure to mention. I am tempted to individually thank all of my friends which, from my childhood until graduate school, have joined me in the discovery of what is life about and how to make the best of it. However, because the list might be too long and by fear of leaving someone out, I will simply say thank you very much to you all. It is a pleasure to express my gratitude wholeheartedly to Anamik Shah’s family for their kind hospitality during my stay in Rajkot for Ph.D. Specially thanks to Ranjanmam and Aditya. Where would I be without my family? My parents deserve special mention for their inseparable support and prayers. My Father Savdasbhai, in the first place is the person who put the fundament of my learning character, showing me the joy of intellectual pursuit ever
since I was a child. My Mother Hansaben, is the one who sincerely raised me with her caring and gently love. My special gratitude is due to my dadi, my brother Kalpesh, Bhabhi Jayshreeben, my sisters Manisha, Jiju Rajnibhai, Sweet Miral, Mahek, Nancy, & Man, my uncle Manshukhbhai and his family for their loving support. Words fail me to express my appreciation to my wife Trupti whose dedication, love and persistent confidence in me, has taken the load off my shoulder. I owe her for being unselfishly let her intelligence, passions, and ambitions collide with mine. Therefore, I would also thank Tupi’s family for letting me take her hand in marriage, and accepting me as a member of the family, warmly. Furthermore, to Sorathiya family with their thoughtful support, thank you. I would like to thank everybody who was important to the successful realization of thesis, as well as expressing my apology to those whose name I could not mention individually. Finally, I bow my head before almighty GOD, who has inspired ME in each and every stage of my life. BHARAT SAVALIA
Page 1 and 2: Saurashtra University Re - Accredit
Page 3: JANUARY-2011 Statement under O. Ph.
Page 7: Acknowledgment This thesis arose in
Page 11 and 12: CHAPTER - 2 Microwave Assisted Synt
Page 13 and 14: 5.5 Results and discussion 156 5.6
Page 15 and 16: Ms Mesyl MW Microwave NBS N-bromosu
Page 17 and 18: 1. Microwave Assisted Organic Synth
Page 19 and 20: 1.4 Heating Mechanism In microwave
Page 21 and 22: 1.5. Effects of solvents Every solv
Page 23 and 24: 1.7 Application of microwave in org
Page 25 and 26: aromatic amines, Lancini’s group
Page 27 and 28: 1.9 2-Aminoimidazole Alkaloids The
Page 29 and 30: Recently group of Erik 83 described
Page 31 and 32: 1.10 Methods for the preparation of
Page 33 and 34: R 1 O X R 2 NH 2 H 2N NAc R 1 HN R
Page 35 and 36: this manifold, was reported in 1925
Page 37 and 38: Another route to 4(5)-acyl-2-amino-
Page 39 and 40: this series of compounds against th
Page 41 and 42: documented. Extra care is needed be
Page 43 and 44: Very recently the research group of
Page 45 and 46: OH a,b O N H2N N Boc N 3 H N R N N
Page 47 and 48: 1.12.2 Biofilm Growth Cycle 1) Plan
Page 49 and 50: can survive both the onslaught of a
Page 51 and 52: [26] Leadbeater, N. E. (2004) Chemi
Page 53 and 54: [86] Kreutzberger, A. (1962) J. Org
Page 55 and 56: Microwave Assisted Synthesis & Stru
Page 57 and 58: 2.1 Introduction As described in ch
Page 59 and 60:
2.3 Proposed Mechanism: Regarding t
Page 61 and 62:
No. 12 60 120 traces 84 a All react
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the development of biofilm related
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In first instance, a series of 2-hy
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Br N N N R 1 OH Br N N N R 1 OH Fig
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do have a very strong effect agains
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2.6 Conclusion In the present study
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2.8 Biological assays 2.8.1 Static
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2.9 Experimental protocol: 2.9.1 Ge
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temperature of 80 °C and a maximum
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29.5,29.4, 29.2, 27.0, 22.6, 14.1.
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Yield: 78 %. 1 H NMR (300 MHz, CDCl
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N Br N N C 14H 29 OH Yield: 72 %. 1
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(75.5 MHz, CDCl3): δ = 167.7, 154.
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N Br N N C 14H 29 OH Cl Yield: 90 %
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2-(3,4-Dichlorophenyl)-2-hydroxy-1-
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N Br N N C 8H 17 OH NO 2 Yield: 49
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C3H7 HN N N H Cl Cl Yield : 70 %. 1
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(s, 1H), 3.16 (s, 3H), 1.80 (m, 2H)
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5-(4’-Nitrobiphenyl-4-yl)-N-octyl
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2.11 Representative NMR spectra 2.1
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2.11.3 10.4329 0.7429 151.5720 10.0
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[21] Matz C, McDougald D, Moreno A.
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Chapter-3 Structure Activity Relati
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imidazoles, where the addition of a
Page 109 and 110:
3.4 Result and Discussion It was fo
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No. H 2N Compound Code N N C8H17 R1
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medium used in the set-up to monito
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H 2N N N N H2N N R R Figure-1 Effec
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3.5.3 Cyclo-alkyl 2-aminoimidazoles
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3.6. Conclusion In the present stud
Page 121 and 122:
3.8. Experimental protocols 3.8.1 G
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122.6, 54.6, 33.3(×2), 27.3 (×2),
Page 125 and 126:
Page 127 and 128:
5-(4-Chlorophenyl)-1-cyclooctyl-1H-
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Yield: 50 %. Mp: 76-78 ° C. 1 H NM
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5-(4-Chlorophenyl)-1-cyclobutyl-1H-
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Yield: 66%. 1 H NMR (300 MHz, CDCl3
Page 135 and 136:
3.10 Representative NMR spectra 3.1
Page 137 and 138:
3.11 References [1] (a) Alvi K. A,
Page 139 and 140:
Copper Catalyzed Microwave Assisted
Page 141 and 142:
4.1 Introduction There are only a f
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(Table-1, No- 6). Next reaction tem
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No. Product, Yield b (%) No. Produc
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4.4 Possible Mechanism Regarding th
Page 149 and 150:
4.7 Experimental protocols 4.7.1 Ge
Page 151 and 152:
Page 153 and 154:
1-(3-Azidopropyl)-2-(3,4-dichloroph
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Yield: 84 %. 1 H NMR (300 MHz, DMSO
Page 157 and 158:
Page 159 and 160:
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1H), 1.66 (m, 6H), 1.70 (m, 2H). 13
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5.48 Hz, 2H), 3.59 (m, 2H), 3.16 (d
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4.10 References [1] For a general r
Page 167 and 168:
Crystal and Molecular Structure Ana
Page 169 and 170:
5.1 Introduction The membrane efflu
Page 171 and 172:
oscillation range of 5˚ and proces
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C12-C13 1.372(4) C32-C37 1.390(3) C
Page 175 and 176:
Fig.-3: Packing of the molecules wh
Page 177 and 178:
1 H NMR (400 MHz CDCl3): δ = 7.57-
Page 179 and 180:
5.9.2 13 C spectra of bs-DP-7
Page 181 and 182:
SUMMARY The work represented in the
Page 183 and 184:
CONFERENCES/SEMINARS/WORKSHOPS ATTE
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PUBLICATIONS [1] One-Pot Microwave-
Page 200 and 201:
Scheme 2 Competitive formation of 1
Page 202 and 203:
Table 2 continued 9 10 11 12 N hydr
Page 204:
8. Colson G, Raboult L, Lavelle F,
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