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Br
N
N
N R 1
OH
Br
N
N
N R 1
OH
Figure-1A: Effect of the length of the n-alkyl chain at the 1-position of 2-hydroxy-2-
phenyl-2,3-dihydro-imidazo[1,2-a]pyrimidinium salts, substituted with Cl and H at
the para-position of the 2-phenyl ring, on the IC50 (µM) for inhibition of biofilm
formation of S. Typhimurium ATCC14028.
2.5.2.2 Further Modification in the most active core structure
Since the compounds with a n-octyl chain substituted at the 1-position have the
highest activity against Salmonella biofilms and also have a high activity against
Pseudomonas biofilms, we decided to synthesize the additional 1-octyl-2-hydroxy-2phenyl-2,3-dihydro-imidazopyrimidinium
salts with more variation in the substitution
pattern of the 2-phenyl ring. As depicted in Table 5 these compounds generally inhibit
biofilm formation of S. Typhimurium at low concentrations. However, no improved
activity was observed in comparison with the previously described compounds (Table
2). The effect of the n-octyl substituted compounds on the biofilm formation of P.
aeruginosa strongly depends on the substitution pattern of the 2-phenyl ring, as some
Cl