Download (8Mb) - Etheses - Saurashtra University
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yl)methyl<br />
3 BS-140* C3H7 3,4-(di-Cl) 70<br />
4 BS-141* cyclohexane 4-SO2Me 43<br />
5 BS-143* C8H17 4-Cl 43<br />
6 BS-146* C5H11 4-Cl 57<br />
7 BS-147* C6H13 4-F 61<br />
8 BS-148* 4-methoxyphenethyl 3-Br 44<br />
9 BS-154* cyclooctane 4-SO2Me 53<br />
10 BS-139* 2-methoxyethyl 4-CN 55<br />
11 BS-258 C8H17 4-OCH3 78<br />
12 BS-259 C8H17 4-F 69<br />
13 BS-260 C8H17 3,4-(di-Cl) 72<br />
14 BS-261 C8H17 3-Br 79<br />
15 BS-262 C8H17 naphthalen-1-yl 68<br />
16 BS-263 C8H17 4-NO2 66<br />
17 BS-264 C8H17 4-(4-NO2Ph) 75<br />
18 BS-265 C8H17 SO2Me 54<br />
19 BS-292 i-Bu 4-NO2 70<br />
20 BS-293 i-Bu H 71<br />
21 BS-294 i-Bu 4-Br 69<br />
22 BS-295 i-Bu 4-Cl 73<br />
*Compounds have been synthesized via One-pot protocol (Scheme-3).<br />
All compounds are either oily or amorphous solid.<br />
Table-2: Microwave assisted synthesis of substituted 2-amino-1H-imidazoles.<br />
2.5 Biofilm activity:<br />
Bacteria are able to switch between a planktonic life style and a biofilm mode of<br />
growth, in which they live as structured communities of bacterial cells enclosed in a<br />
self-produced polymeric matrix and adherent to an inert or living surface. 17 As<br />
bacteria in biofilms are more resistant to challenges from predators, antibiotics,<br />
disinfectants and host immune systems, 18-21 serious problems and high costs have<br />
been associated with biofilms, both in medicine and industrial settings. According to<br />
the National Institutes of Health, more than 80% of microbial infections are related to<br />
biofilms. 22 Especially the use of indwelling medical devices comprises a high risk for