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yl)methyl
3 BS-140* C3H7 3,4-(di-Cl) 70
4 BS-141* cyclohexane 4-SO2Me 43
5 BS-143* C8H17 4-Cl 43
6 BS-146* C5H11 4-Cl 57
7 BS-147* C6H13 4-F 61
8 BS-148* 4-methoxyphenethyl 3-Br 44
9 BS-154* cyclooctane 4-SO2Me 53
10 BS-139* 2-methoxyethyl 4-CN 55
11 BS-258 C8H17 4-OCH3 78
12 BS-259 C8H17 4-F 69
13 BS-260 C8H17 3,4-(di-Cl) 72
14 BS-261 C8H17 3-Br 79
15 BS-262 C8H17 naphthalen-1-yl 68
16 BS-263 C8H17 4-NO2 66
17 BS-264 C8H17 4-(4-NO2Ph) 75
18 BS-265 C8H17 SO2Me 54
19 BS-292 i-Bu 4-NO2 70
20 BS-293 i-Bu H 71
21 BS-294 i-Bu 4-Br 69
22 BS-295 i-Bu 4-Cl 73
*Compounds have been synthesized via One-pot protocol (Scheme-3).
All compounds are either oily or amorphous solid.
Table-2: Microwave assisted synthesis of substituted 2-amino-1H-imidazoles.
2.5 Biofilm activity:
Bacteria are able to switch between a planktonic life style and a biofilm mode of
growth, in which they live as structured communities of bacterial cells enclosed in a
self-produced polymeric matrix and adherent to an inert or living surface. 17 As
bacteria in biofilms are more resistant to challenges from predators, antibiotics,
disinfectants and host immune systems, 18-21 serious problems and high costs have
been associated with biofilms, both in medicine and industrial settings. According to
the National Institutes of Health, more than 80% of microbial infections are related to
biofilms. 22 Especially the use of indwelling medical devices comprises a high risk for