[56] Garbacia, S.; Desai, B.; Lavastre, O.; Kappe, C. O. (2003) J. Org. Chem. 68, [57] Laurent, A.; Jacquault, P.; Di Martino, J. L.; Hamelin, (1995) Chem. Commun. 1101. [58] Kad, G. L.; Kaur, I.; Bhandari, M.; Singh, J.; Kaur, J. (2003) J. Org. Proc. Res. Dev. 339-40. [59] Nielsen, T. E., Schreiber, S. L. (2007) Angew. Chem. Int. Ed., 47, 48-56 [60] a) Nören-Müller, A., Reis-Corr a, Jr., I., Prinz, H., Rosenbaum, C., Saxena, K., Schwalbe, H. [61] J., Vestweber, D., Cagna, G., Schunk, S., Schwarz, O., Schiewe, H., Waldmann H. (2006) Proc. Natl. Acad. Sci. USA, 103, 10606-10611. b) Wilk, W., Krishna Saxena, K., Schwalbe, H., Kaiser, M., Waldmann, H. (2008) Angew. Chem. Int. Ed., 47, 5973-5977. Zaborsky, O. R. Plenum Press; New York, N.Y. pp 1-43. [62] Singh, R., Sharma, M., Joshi, P., Rawat, D. S. (2008) Cancer Agents Med. Chem., 8, 603-617. [63] Maeda, K., Osato, T., Umezawa, H. (1953) J. Antibiotics, 6, 182. [64] Nakamura S., Umezawa, H. (1955) J. Antibiotics, 8, 66. [65] Cudmore, S. L., Delgaty, K. L., Hayward-McClelland, S. F., Petrin, D. P., Garber, G. E. (2004) Clin. Micro-biol. Rev., 17, 783-793. [66] Lancini, C. C., Lazari, E., Sartori C. (1968) J. Antibiotics, 6, 387-292. [67] Seki, Y., Nakamura, T., Okami, Y. (1970) J. Biochem., 67, 389-396. [68] Utkina, N. K., Fedoreev, S. A. (1984) Khim. Prir. Soedin., 1, 124-125. [69] Edwards, D. I. (1993) J. Antimicrob. Chemother., 31, 9-20. [70] Reigan, P., Edwards, P. N., Gbaj, A., Cole, C., Barry, S. T., Page, K. M., Ashton, S. E., Luke, R. W. A., Douglas, K. T., Stratford, I. J., Jaffar, M., Bryce, R. A., Freeman, S. (2005) J. Med. Chem., 48, 392-402. [71] Hodgkiss, R. J. (1998) Anti-Cancer Drug Des., 13, 687-702. [72] Naylor, M. A., Threadgill, M. D., Webb, P., Stratford, I. J., Stephens, M. A., Fielden, E. M., Adams, G. E. (1992) J. Med. Chem., 35, 3573-3578. [73] Al Mourabit, A.; Potier, P. Eur. J. Org. Chem. 2001, 237 and references therein. [74] Hofmann, K. (1963) "The Chemistry of Heterocyclic Compounds," Vol. 6, A. Weissburger, Ed., Interscience Publishers, Inc., New York, N. Y., pp. 141-142. [75] Angyal, S. J., Angyal, C. L. (1952) J. Am. Chem. Soc., 74, 1461-1466. [76] Bell, R. P. (1959) Cornel <strong>University</strong> Press, Ithaca, N. Y., p. 96. [77] Storey, B. T., Sullivan, W. W., Moyer, C. L. (1964) J. Org. Chem, 29, 3118-3120. [78] Dardonville, C., Rozas, I., Alkorta, I. (1998) J. Mol. Graphics, 16, 150-156. [79] Ayrton, A., Morgan, P. (2001) Xenobiotica, 31, 469-497. [80] E. Fattorusso, O. Taglialatela-Scafati, Modern alkaloids: structure, isolation, synthesis and biology, John Wiley, Weinheim, 2008. [81] A. E. Wright; S. A. Chiles, S. S. Cross, Nat. Prod. Rep. 1991, 54, 1684–1686. [82] D. J. Faulkner, Nat. Prod. Rep. 2001, 18, 1–49. [83] D. S. Ermolat’ev, J.B. Bariwal, H. P. L. Steenackers, S. C. J. De Keersmaecker, E. V. Van der Eycken (2010), Angew. Chem. Int. Ed. 2010, 49, 9465 –9468 [84] Norris, T. O., McKee, R. L. (1954) J. Am. Chem. Soc., 77, 1056. [85] Lawson, A. (1956) J. Chem. Soc., 307-310.
[86] Kreutzberger, A. (1962) J. Org. Chem., 27, 886-891. [87] Lancini, G. C., Lazzari, E. (1966) J. Antibiotics, 3, 152-154. [88] Lancini, G. C., Lazzari, E., Arioli, V., Bellani, P. (1969) J. Med. Chem., 12, 775-780. [89] Burtles, R., Pyman, F. L. (1925) J. Chem. Soc., 2012-2018. [90] Little, T. L., Webber, S. E. (2004) J. Org. Chem., 59, 7299-7305. [91] Nishimura, T., Kitajima, K. (1979) J. Org. Chem., 44, 818-824. [92] Marchais, S., Al-Mourabit, A., Poupat, C., Potier, P. (1998) Tetrahedron Lett., 39, 8085-8088. [93] Sosa, A. C. B., Yakushijin, K., Horne, D. A. (2000) J. Org. Chem., 65, 610-611. [94] Xu, Y.-Z., Yakushijin, K., Horne, D. A. (1997) J. Org. Chem., 62, 456-464. [95] Hassner, A., Munger, P., Belinka, Jr., B. A. (1982Tetrahedron Lett., 23, 699-702. [96] Daninos, S., Al Mourabit, A., Ahond, A., Zurita, M. B., Poupat, C., Potier, P. (1994) Bull. Soc. Chim. Fr., 131, 590-599. [97] Danios-Zegal, S., Mourabit, A. A., Poupat, C., Potier, P. (1997) Tetrahedron., 53, 7605-7614. [98] Jarosinski, M. A., Anderson, K. A. (1991) J. Org. Chem., 56, 4058-4062. [99] Meketa, M. L., Weinreb, S. M. (2006) Org. Lett., 8, 1443-1446. [100] Meketa, M. L., Weinreb, S. M. (2007). Org. Lett., 9, 853-855. [101] Kawasaki, I., Sakaguchi, N., Fukushima, N., Fujioka, N., Nikaido, F, Yamashita, M., Ohta, S. (2002) Tetrahedron, 43, 4377-4380. [102] Kawasaki, I., Sakaguchi, N., Khadeer, A., Yamashita, M., Ohta, S. (2006) Tetrahedron, 62, 10182-10192. [103] Piccionello, A. P., Pace, A., Vivona, N., Pani, M. (2008) Tetrahedron, 64, 4004-4010. [104] LaMattina, J. L.; Mularski, C. J. Tetrahedron. Lett. 1984, 25, 2957. [105] Jung, F., Delvare, C., Hamon, A., Ackerley, N., Betts, M. J. (1991) 34, 1110-1116. [106] Jung, F., Boucherot, D., Delvare, C., Olivier, A., Davies, G. M., Betts, M. J., Brown, R., Stevenson, R., Jospeh, M., Kingston, J. F., Pittam, J. D. (1993) J. Antibiotics, 46, 992-1012. [107] Wilkerson, W. W., Dax, S., Cheatham, W. W. (1997) J. Med. Chem., 40, 4079-4088. [108] Maze, M., Tranquilli, W. (1991) Anesthesiology, 74, 581-605. [109] Munk, S. A., Harcourt, D. A., Arasasingham, P. N., Burke, J, A., Kharlamb, A. B., Manlapaz, C. A., Padillo, E. U., Roberts, D., Runde, E. (1997) J. Med. Chem., 40, 18-23. [110] Makabe, R. (1966) Dtsch. Med. Wochenschr., 91, 1686-1688. [111] Wen-Tai Li, Der-Ren Hwang, Jen-Shin Song, Ching-Ping Chen, Jiunn-Jye Chuu,Chih-Bo Hu, Heng-Liang Lin,Chen-Lung Huang,, Chiung-Tong Chen (2010), J. Med. Chem. DOI: 10.1021/jm901501s [112] Shawn J. Stachel, Craig A. Coburn, Diane Rush, Samuel L. Grahama, Sanjeev K. Munshi, Joseph P. Vacca. (2009), Bioorganic & Medicinal Chemistry Letters. 19 2977–2980 [113] Ivory D. Hills, M. Katharine Holloway, Tim J. Allison, Dennis Colussi, Shawn J. Stachel. (2009), Bioorganic & Medicinal Chemistry Letters 19 4993–4995 [114] Donlan, R. M.; Costerton, J. W. (2002), Clin. Microbiol. Rev. 15, 167. [115] Richards, J. J.; Melander, C. (2009), Anti-Infect. Agents Med. Chem. 8, 295. [116] Davies, D. (2003), Nat. Rev. Drug Disc., 2, 114.
- Page 1 and 2: Saurashtra University Re - Accredit
- Page 3: JANUARY-2011 Statement under O. Ph.
- Page 7 and 8: Acknowledgment This thesis arose in
- Page 9 and 10: since I was a child. My Mother Hans
- Page 11 and 12: CHAPTER - 2 Microwave Assisted Synt
- Page 13 and 14: 5.5 Results and discussion 156 5.6
- Page 15 and 16: Ms Mesyl MW Microwave NBS N-bromosu
- Page 17 and 18: 1. Microwave Assisted Organic Synth
- Page 19 and 20: 1.4 Heating Mechanism In microwave
- Page 21 and 22: 1.5. Effects of solvents Every solv
- Page 23 and 24: 1.7 Application of microwave in org
- Page 25 and 26: aromatic amines, Lancini’s group
- Page 27 and 28: 1.9 2-Aminoimidazole Alkaloids The
- Page 29 and 30: Recently group of Erik 83 described
- Page 31 and 32: 1.10 Methods for the preparation of
- Page 33 and 34: R 1 O X R 2 NH 2 H 2N NAc R 1 HN R
- Page 35 and 36: this manifold, was reported in 1925
- Page 37 and 38: Another route to 4(5)-acyl-2-amino-
- Page 39 and 40: this series of compounds against th
- Page 41 and 42: documented. Extra care is needed be
- Page 43 and 44: Very recently the research group of
- Page 45 and 46: OH a,b O N H2N N Boc N 3 H N R N N
- Page 47 and 48: 1.12.2 Biofilm Growth Cycle 1) Plan
- Page 49 and 50: can survive both the onslaught of a
- Page 51: [26] Leadbeater, N. E. (2004) Chemi
- Page 55 and 56: Microwave Assisted Synthesis & Stru
- Page 57 and 58: 2.1 Introduction As described in ch
- Page 59 and 60: 2.3 Proposed Mechanism: Regarding t
- Page 61 and 62: No. 12 60 120 traces 84 a All react
- Page 63 and 64: the development of biofilm related
- Page 65 and 66: In first instance, a series of 2-hy
- Page 67 and 68: Br N N N R 1 OH Br N N N R 1 OH Fig
- Page 69 and 70: do have a very strong effect agains
- Page 71 and 72: 2.6 Conclusion In the present study
- Page 73 and 74: 2.8 Biological assays 2.8.1 Static
- Page 75 and 76: 2.9 Experimental protocol: 2.9.1 Ge
- Page 77 and 78: temperature of 80 °C and a maximum
- Page 79 and 80: 29.5,29.4, 29.2, 27.0, 22.6, 14.1.
- Page 81 and 82: Yield: 78 %. 1 H NMR (300 MHz, CDCl
- Page 83 and 84: N Br N N C 14H 29 OH Yield: 72 %. 1
- Page 85 and 86: (75.5 MHz, CDCl3): δ = 167.7, 154.
- Page 87 and 88: N Br N N C 14H 29 OH Cl Yield: 90 %
- Page 89 and 90: 2-(3,4-Dichlorophenyl)-2-hydroxy-1-
- Page 91 and 92: N Br N N C 8H 17 OH NO 2 Yield: 49
- Page 93 and 94: C3H7 HN N N H Cl Cl Yield : 70 %. 1
- Page 95 and 96: (s, 1H), 3.16 (s, 3H), 1.80 (m, 2H)
- Page 97 and 98: 5-(4’-Nitrobiphenyl-4-yl)-N-octyl
- Page 99 and 100: 2.11 Representative NMR spectra 2.1
- Page 101 and 102: 2.11.3 10.4329 0.7429 151.5720 10.0
- Page 103 and 104:
[21] Matz C, McDougald D, Moreno A.
- Page 105 and 106:
Chapter-3 Structure Activity Relati
- Page 107 and 108:
imidazoles, where the addition of a
- Page 109 and 110:
3.4 Result and Discussion It was fo
- Page 111 and 112:
No. H 2N Compound Code N N C8H17 R1
- Page 113 and 114:
medium used in the set-up to monito
- Page 115 and 116:
H 2N N N N H2N N R R Figure-1 Effec
- Page 117 and 118:
3.5.3 Cyclo-alkyl 2-aminoimidazoles
- Page 119 and 120:
3.6. Conclusion In the present stud
- Page 121 and 122:
3.8. Experimental protocols 3.8.1 G
- Page 123 and 124:
122.6, 54.6, 33.3(×2), 27.3 (×2),
- Page 125 and 126:
Yield: 52 %. 1 H NMR (300 MHz, CDCl
- Page 127 and 128:
5-(4-Chlorophenyl)-1-cyclooctyl-1H-
- Page 129 and 130:
Yield: 50 %. Mp: 76-78 ° C. 1 H NM
- Page 131 and 132:
5-(4-Chlorophenyl)-1-cyclobutyl-1H-
- Page 133 and 134:
Yield: 66%. 1 H NMR (300 MHz, CDCl3
- Page 135 and 136:
3.10 Representative NMR spectra 3.1
- Page 137 and 138:
3.11 References [1] (a) Alvi K. A,
- Page 139 and 140:
Copper Catalyzed Microwave Assisted
- Page 141 and 142:
4.1 Introduction There are only a f
- Page 143 and 144:
(Table-1, No- 6). Next reaction tem
- Page 145 and 146:
No. Product, Yield b (%) No. Produc
- Page 147 and 148:
4.4 Possible Mechanism Regarding th
- Page 149 and 150:
4.7 Experimental protocols 4.7.1 Ge
- Page 151 and 152:
Yield: 69 %. 1 H NMR (300 MHz, CDCl
- Page 153 and 154:
1-(3-Azidopropyl)-2-(3,4-dichloroph
- Page 155 and 156:
Yield: 84 %. 1 H NMR (300 MHz, DMSO
- Page 157 and 158:
Yield: 80 %. 1 H NMR (300 MHz, DMSO
- Page 159 and 160:
Yield: 83 %. 1 H NMR (300 MHz, DMSO
- Page 161 and 162:
1H), 1.66 (m, 6H), 1.70 (m, 2H). 13
- Page 163 and 164:
5.48 Hz, 2H), 3.59 (m, 2H), 3.16 (d
- Page 165 and 166:
4.10 References [1] For a general r
- Page 167 and 168:
Crystal and Molecular Structure Ana
- Page 169 and 170:
5.1 Introduction The membrane efflu
- Page 171 and 172:
oscillation range of 5˚ and proces
- Page 173 and 174:
C12-C13 1.372(4) C32-C37 1.390(3) C
- Page 175 and 176:
Fig.-3: Packing of the molecules wh
- Page 177 and 178:
1 H NMR (400 MHz CDCl3): δ = 7.57-
- Page 179 and 180:
5.9.2 13 C spectra of bs-DP-7
- Page 181 and 182:
SUMMARY The work represented in the
- Page 183 and 184:
CONFERENCES/SEMINARS/WORKSHOPS ATTE
- Page 185:
PUBLICATIONS [1] One-Pot Microwave-
- Page 200 and 201:
Scheme 2 Competitive formation of 1
- Page 202 and 203:
Table 2 continued 9 10 11 12 N hydr
- Page 204:
8. Colson G, Raboult L, Lavelle F,