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can survive both the onslaught of antibiotic treatment and the immune system. When
the concentration of antibiotic reduces, persisters can repopulate the biofilm, which
will shed off new planktonic cells, producing the relapsing biofilm infection. The
problem of biofilm resistance 72 to killing by most therapeutics probably defaults to
persisters. Interestingly, yeast biofilms also form tolerant persisters.
1.13 Recent publications on 2-aminoimidazoles.
The core structure 2-aminoimidazole has assumed importance in various synthesis
related to heterocyclic in drug synthesis as appeared in Sci-finder search results on the
basis of number of publications in medicinal and synthetic chemistry journals.
Fig.1.10 Sci-finder search results by heating term 2-aminoimidazole.
1.14 Conclusion
Bacterial biofilms pose a serious threat to the healthcare system of our society as they
are responsible for the morbidity and mortality of a myriad of diseases. The
development of antibiotic resistance among many bacterial strains has put a
tremendous pressure on the medical community to find alternative approaches for the
treatment of biofilm-mediated diseases. In this present work of thesis a microwave
assisted synthesis of small molecules which shows ability to controlling bacterial
antibiofilm has been reported.