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Empirical formula C33H27NO3 Formula weight 485.56 Temperature 293 k Wavelength 0.71073 Å Crystal system Triclinic Space group Pī a = 7.4310(6Å), b =12.2580(16)Å, c = Cell dimensions 14.4180(17)Å, α = 92.066(3)˚, β=95.319(7)˚, γ= 96.235(7)˚ Volume 1298.5(3)Å 3 Z 2 Density(calculated) 1.242Mg/m 3 Absorption coefficient 0.079 mm -1 F000 Crystal size 0.30 x 0.27 x 0.25 mm Theta range for data collection 3.07˚ to 25.02˚ Index ranges -8
C12-C13 1.372(4) C32-C37 1.390(3) C13-C14 1.383(4) C33-C34 1.382(3) C13-O15 1.392(3) C34-C35 1.372(4) O15-C16 1.387(3) C35-C36 1.379(4) C16-C17 1.353(4) C36-C37 1.378(3) C16-C21 1.362(5) Table-2: Bond lengths (Å) Atoms Angle(˚) Atoms Angle(˚) C2-N1-C6 122.62(2) C21-C16-O15 117.5(3) N1-C2-C3 118.10(2) C16-C17-C18 118.2(3) N1-C2-C8 113.33(2) C19-C18-C17 119.5(4) C3-C2-C8 128.53(2) C20-C19-C18 121.0(4) C2-C3-C30 126.66(2) C19-C20-C21 120.7(4) C2-C3-C4 118.06(2) C20-C21-C16 119.1(3) C30-C3-C4 115.09(2) O23-C22-C5 123.7(2) C3-C4-C5 108.93(1) O23-C22-C24 119.5(2) C3-C4-C9 114.15(2) C5-C22-C24 116.65(2) C5-C4-C9 109.54(2) C25-C24-C29 118.8(3) C6-C5-C22 122.16(2) C25-C24-C22 121.4(2) C6-C5-C4 118.62(2) C29-C24-C22 119.7(2) C22-C5-C4 119.04(2) C26-C25-C24 120.6(3) C5-C6-N1 117.99(2) C27-C26-C25 119.9(3) C5-C6-C7 127.0(2) C26-C27-C28 120.0(3) N1-C6-C7 114.96(2) C27-C28-C29 120.9(3) C10-C9-C14 117.8(2) C28-C29-C24 119.8(3) C10-C9-C4 123.18(2) O31-C30-C3 118.58(2) C14-C9-C4 118.97(2) O31-C30-C32 117.36(2) C9-C10-C11 120.7(2) C3-C30-C32 123.99(2) C12-C11-C10 121.3(3) C33-C32-C37 119.10(2) C11-C12-C13 118.6(2) C33-C32-C30 118.92(2) C12-C13-C14 121.0(2) C37-C32-C30 121.67(2) C12-C13-O15 116.8(2) C34-C33-C32 120.4(2) C14-C13-O15 122.0(3) C35-C34-C33 120.1(2) C13-C14-C9 120.5(2) C34-C35-C36 119.9(2) C16-O15-C13 119.0(2) C37-C36-C35 120.6(2) C17-C16-C21 121.5(3) C36-C37-C32 119.9(2) C17-C16-O15 120.8(3) Table-3: Bond angles (˚) Atoms Length (Å) Angle(˚) Symmetry codes N1–H1. . .O31 2.999(2) 156 1 + x, y, z Table-4: Hydrogen bonding geometry
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Saurashtra University Re - Accredit
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JANUARY-2011 Statement under O. Ph.
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Acknowledgment This thesis arose in
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since I was a child. My Mother Hans
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CHAPTER - 2 Microwave Assisted Synt
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5.5 Results and discussion 156 5.6
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Ms Mesyl MW Microwave NBS N-bromosu
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1. Microwave Assisted Organic Synth
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1.4 Heating Mechanism In microwave
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1.5. Effects of solvents Every solv
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1.7 Application of microwave in org
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aromatic amines, Lancini’s group
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1.9 2-Aminoimidazole Alkaloids The
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Recently group of Erik 83 described
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1.10 Methods for the preparation of
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R 1 O X R 2 NH 2 H 2N NAc R 1 HN R
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this manifold, was reported in 1925
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Another route to 4(5)-acyl-2-amino-
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this series of compounds against th
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documented. Extra care is needed be
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Very recently the research group of
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OH a,b O N H2N N Boc N 3 H N R N N
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1.12.2 Biofilm Growth Cycle 1) Plan
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can survive both the onslaught of a
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[26] Leadbeater, N. E. (2004) Chemi
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[86] Kreutzberger, A. (1962) J. Org
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Microwave Assisted Synthesis & Stru
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2.1 Introduction As described in ch
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2.3 Proposed Mechanism: Regarding t
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No. 12 60 120 traces 84 a All react
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the development of biofilm related
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In first instance, a series of 2-hy
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Br N N N R 1 OH Br N N N R 1 OH Fig
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do have a very strong effect agains
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2.6 Conclusion In the present study
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2.8 Biological assays 2.8.1 Static
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2.9 Experimental protocol: 2.9.1 Ge
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temperature of 80 °C and a maximum
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29.5,29.4, 29.2, 27.0, 22.6, 14.1.
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Yield: 78 %. 1 H NMR (300 MHz, CDCl
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N Br N N C 14H 29 OH Yield: 72 %. 1
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(75.5 MHz, CDCl3): δ = 167.7, 154.
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N Br N N C 14H 29 OH Cl Yield: 90 %
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2-(3,4-Dichlorophenyl)-2-hydroxy-1-
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N Br N N C 8H 17 OH NO 2 Yield: 49
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C3H7 HN N N H Cl Cl Yield : 70 %. 1
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(s, 1H), 3.16 (s, 3H), 1.80 (m, 2H)
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5-(4’-Nitrobiphenyl-4-yl)-N-octyl
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2.11 Representative NMR spectra 2.1
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2.11.3 10.4329 0.7429 151.5720 10.0
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[21] Matz C, McDougald D, Moreno A.
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Chapter-3 Structure Activity Relati
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imidazoles, where the addition of a
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3.4 Result and Discussion It was fo
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No. H 2N Compound Code N N C8H17 R1
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medium used in the set-up to monito
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H 2N N N N H2N N R R Figure-1 Effec
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3.5.3 Cyclo-alkyl 2-aminoimidazoles
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3.6. Conclusion In the present stud
Page 121 and 122: 3.8. Experimental protocols 3.8.1 G
Page 123 and 124: 122.6, 54.6, 33.3(×2), 27.3 (×2),
Page 125 and 126: Yield: 52 %. 1 H NMR (300 MHz, CDCl
Page 127 and 128: 5-(4-Chlorophenyl)-1-cyclooctyl-1H-
Page 129 and 130: Yield: 50 %. Mp: 76-78 ° C. 1 H NM
Page 131 and 132: 5-(4-Chlorophenyl)-1-cyclobutyl-1H-
Page 133 and 134: Yield: 66%. 1 H NMR (300 MHz, CDCl3
Page 135 and 136: 3.10 Representative NMR spectra 3.1
Page 137 and 138: 3.11 References [1] (a) Alvi K. A,
Page 139 and 140: Copper Catalyzed Microwave Assisted
Page 141 and 142: 4.1 Introduction There are only a f
Page 143 and 144: (Table-1, No- 6). Next reaction tem
Page 145 and 146: No. Product, Yield b (%) No. Produc
Page 147 and 148: 4.4 Possible Mechanism Regarding th
Page 149 and 150: 4.7 Experimental protocols 4.7.1 Ge
Page 151 and 152: Yield: 69 %. 1 H NMR (300 MHz, CDCl
Page 153 and 154: 1-(3-Azidopropyl)-2-(3,4-dichloroph
Page 155 and 156: Yield: 84 %. 1 H NMR (300 MHz, DMSO
Page 161 and 162: 1H), 1.66 (m, 6H), 1.70 (m, 2H). 13
Page 163 and 164: 5.48 Hz, 2H), 3.59 (m, 2H), 3.16 (d
Page 165 and 166: 4.10 References [1] For a general r
Page 167 and 168: Crystal and Molecular Structure Ana
Page 169 and 170: 5.1 Introduction The membrane efflu
Page 171: oscillation range of 5˚ and proces
Page 175 and 176: Fig.-3: Packing of the molecules wh
Page 177 and 178: 1 H NMR (400 MHz CDCl3): δ = 7.57-
Page 179 and 180: 5.9.2 13 C spectra of bs-DP-7
Page 181 and 182: SUMMARY The work represented in the
Page 183 and 184: CONFERENCES/SEMINARS/WORKSHOPS ATTE
Page 185: PUBLICATIONS [1] One-Pot Microwave-
Page 200 and 201: Scheme 2 Competitive formation of 1
Page 202 and 203: Table 2 continued 9 10 11 12 N hydr
Page 204: 8. Colson G, Raboult L, Lavelle F,
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