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1H), 1.66 (m, 6H), 1.70 (m, 2H). 13 C NMR (75.5 MHz, DMSO-d6): δ = 161.8, 158.6,
150.3, 146.2, 146.1, 130.9, 125.2, 125.1, 122.2, 115.1, 114.8, 48.9, 42.9, 31.8 (×3),
31.0, 24.5 (×2). HRMS (EI) C19H23FN6, calcd 354.1968., found: 354.1974.
N-(2-(4-Cyclopropyl-1H-1,2,3-triazol-1-yl)ethyl)-5-(4-fluorophenyl)-1H-imidazol-
2-amine (BS-309)
F
N
H
N
N
H
N
N
N
Yield: 80 %. 1 H NMR (300 MHz, DMSO-d6): δ = 10.55 (br s, 1H), 7.79 (s, 1H),
7.64 (m, 2H), 7.10 (t , J = 8.7 Hz, 2H), 7.02 (s, 1H), 5.90 (m, 1H), 4.99 (t, J = 5.85
Hz, 2H), 3.61 (m, 2H), 1.91 (m, 1H), 0.85 (m, 2H), 0.69 (m, 2H). 13 C NMR (75.5
MHz, DMSO-d6): δ = 161.8, 158.6, 150.4, 148.6 (×2), 131.1, 125.1, 125.0, 120.9,
115.1, 114.8, 48.9, 42.9, 7.6(×2), 6.5. HRMS (EI) C16H17FN6, calcd 312.1499., found:
312.1487.
5-(4-Chlorophenyl)-N-(2-(4-cyclopentyl-1H-1,2,3-triazol-1-yl)ethyl)-4-p-tolyl-1Himidazol-2-amine(BS-310-B)
Cl
N
H
N
N
H
N
N
N
Yield: 16 %. 1 H NMR (300 MHz, DMSO-d6): δ = 10.89 (br s, 1H), 7.84 (s, 1H), 7.40
(m, 2H), 7.29 (m, 4H), 7.14 (m, 2H), 5.87 (m, 1H), 4.52 (t, J = 5.87 Hz, 2H), 3.64 (m,
2H), 3.06 (m, 1H), 2.29 (s, 3H), 1.95 (m, 2H), 1.60 (m, 6H). 13 C NMR (75.5 MHz,
DMSO-d6): δ = 150.9, 150.1, 135.7, 130.0, 128.9 (×3), 128.1 (×3), 128.0 (×2), 127.2
(×3), 121.1, 104.1, 49.0, 42.7, 36.1, 32.7 (×2), 24.6 (×2), 20.7. HRMS (EI)
C25H27ClN6. calcd.446.1986, found: 446.1990.