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(2-(3-(4-Propyl-1H-1,2,3-triazol-1-yl)propylamino)-1H-imidazol-5yl)(morpholino)methanone
(BS-306)
O
O
N
N
H
N
N
H
N
N N
C 3H 7
Yield: 29 %. 1 H NMR (300 MHz, DMSO-d6): δ = 10.02 (br s, 1H), 7.85 (s, 1H), 7.10
(s, 1H), 6.05 (m, 1H), 4.35 (t, J = 6.8 Hz, 2H), 3.75 (m, 4H), 3.57 (t, J = 4.31 Hz, 4H),
3.10 (m, 2H), 2.57 (t, J = 7.42 Hz, 2H), 2.05 (m, 2H), 1.60 (m, 2H), 0.90 (t, J = 7.42
Hz, 3H). 13 C NMR (75.5 MHz, DMSO-d6): δ = 161.2, 150.1, 146.6, 122.8, 121.7
(×2), 66.3 (×2), 54.8 (×2), 46.9, 44.4, 29.9, 27.0, 22.2, 13.5. HRMS (EI) C16H25N7O2,
calcd 347.2070., found: 347.2085.
(2-(2-(4-Propyl-1H-1,2,3-triazol-1-yl)ethylamino)-1H-imidazol-5yl)(morpholino)methanone
(BS-307)
O
O
N
N
H
N
N
H
N
N
N
C 3H 7
Yield: 29 %. 1 H NMR (300 MHz, DMSO-d6): δ = 10.89 (br s, 1H), 7.78 (s, 1H), 7.08
(s, 1H), 5.98 (m, 1H), 4.45 (m, 2H), 3.74 (m, 3H), 3.58 (m, 6H), 3.16 (m, 1H), 2.56
(m, 2H), 1.57 (m, 2H), 0.89 (t, J = 7.25 Hz, 3H). 13 C NMR (75.5 MHz, DMSO-d6): δ
= 161.4, 149.7, 146.5 (×2), 121.9 (×2), 66.3 (×2), 48.7 (×2), 44.4, 44.7, 27.0, 22.2,
13.6. HRMS (EI) C15H23N7O2, calcd 333.1913., found: 333.1920.
N-(2-(4-(Cyclopentylmethyl)-1H-1,2,3-triazol-1-yl)ethyl)-5-(4-fluorophenyl)-1Himidazol-2-amine
(BS-308)
F
N
H
N
N
H
N
N
N
Yield: 68 %. 1 H NMR (300 MHz, DMSO-d6): δ = 10.63 (br s, 1H), 7.82 (s, 1H),
7.63 (q, J = 2.9, 5.7 Hz, 2H), 7.11 (t , J = 8.7 Hz, 2H), 7.03 (s, 1H), 5.96 (t, J = 5.4
Hz, 1H), 4.51 (t, J = 5.99 Hz, 2H), 3.61 (m, 2H), 2.59 (d, J = 7.08 Hz, 2H), 2.07 (m,