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5-(3,4-Dichlorophenyl)-N-(2-(4-cyclohexyl-1H-1,2,3-triazol-1-yl)ethyl)-1Himidazol-2-amine
(BS-301)
Cl
Cl
N
H
N
N
H
N
N
N
Yield: 85 %. 1 H NMR (300 MHz, DMSO-d6): δ = 10.64 (br s, 1H), 7.58 (s, 1H), 7.80
(s, 1H), 7.60 (m, 1H), 7.48 (d, J = 8.3 Hz, 1H), 7.24 (s, 1H), 6.00 (m, 1H), 4.50 (t, J =
5.76 Hz, 2H), 3.61 (m, 2H), 2.61 (m, 1H), 1.91 (m, 2H), 1.69 (m, 3H), 1.32 (m,5H).
13
C NMR (75.5 MHz, DMSO-d6): δ = 151.9, 150.6, 131.0 (×2), 130.3, 126.6 (×2),
124.7, 123.4, 120.7, 104.1, 54.8, 49.0, 42.8, 34.5, 32.4 (×2), 25.5 (×2).HRMS (EI)
C19H22Cl2N6, calcd 404.1283., found: 404.1278.
5-(3,4-Dichlorophenyl)-N-(2-(4-propyl-1H-1,2,3-triazol-1-yl)ethyl)-1H-imidazol-
2-amine (BS-302)
Cl
Cl
N
H
N
N
H
N
N
N
C 3H 7
Yield: 90 %. 1 H NMR (300 MHz, DMSO-d6): δ = 10.80 (br s, 1H), 7.84 (d, J = 1.7
Hz, 1H), 7.82 (s, 1H), 7.59 (d of d, J = 8.4, 1.7 Hz, 1H), 7.53 (d, J = 8.4 Hz, 1H), 7.26
(s, 1H), 6.14 (br s, 1H), 4.51 (t, J = 6.04 Hz, 2H), 3.62(m, 2H), 2.56 (t, J = 7.49 Hz,
2H), 1.57 (m, 2H), 0.89 (t, J = 7.25 Hz, 3H). 13 C NMR (75.5 MHz, DMSO-d6): δ =
150.4, 146.5, 135.0, 131.0 (×2), 130.4 126.8 (×2), 124.8, 123.5, 122.0, 48.8, 42.8,
27.0, 22.0, 13.6. HRMS (EI) C16H18Cl2N6, calcd 364.0970., found: 364.0980.
5-(3,4-Dichlorophenyl)-N-(3-(4-propyl-1H-1,2,3-triazol-1-yl)propyl)-1Himidazol-2-amine
(BS-303)
Cl
Cl
N
N
H
N
H
N
N N
C 3H 7