Download (8Mb) - Etheses - Saurashtra University

More documents

Recommendations

Info

4.7.4 General Procedure for the preparation of 2-AI-T. Cool the suspension of hydrazine hydride (2 equiv), in ethanol (0.8 ml.). To the suspension were added Cu(OAc)2 (5 mol %) in water (0.2 ml). and stirred it for 2 min at 0 o C. To this were added acetylene (1.5 eq) and hydroxyl salt (1 eq.) The reaction mixture was irradiated at 100 0 o C at the maximum power 35 W for 2-5 min. After completion of the reaction, the solvent was removed under reduce pressure. The crude product was purifier by column chromatography over silica gel using DCM / methanol / 7N methanolic NH3 (96:3:1) as the eluent. 4.8 Spectral Characterization 2-Azidoethanamine (BS-167) H 2N Yield: 41 %. 1 H NMR (300 MHz, CDCl3): δ = 3.37 (t, J = 5.61 Hz, 2H), 2.88 (t, J = 5.50 Hz, 2H), 1.53 (Br s, 2H). 3-Azidopropan-1-amine (BS-220) H 2N Yield: 45 %. 1 H NMR (300 MHz, CDCl3): δ = 3.38 (t, J = 6.93 Hz, 2H), 2.81 (t, J = 6.84 Hz, 2H), 1.73 (m, 2H), 1.36 (Br s, 2H). N-(2-Azidoethyl)pyrimidin-2-amine (BS-168) N N N H Yield: 67 %. 1 H NMR (300 MHz, CDCl3): δ = 8.30 (d, J = 4.74 Hz, 2H), 6.58 (t, J = 4.74 Hz, 1H), 5.44 (Br s, 1H), 3.64 (m, 2H), 3.54 (t, J = 5.58 Hz, 2H), 13 C NMR (75.5 MHz, CDCl3): δ =162.0, 158.1, 158.0, 111.1, 50.8, 40.7. HRMS (EI) C6H6N6, calcd 164.0810, found :. N-(3-Azidopropyl)pyrimidin-2-amine (BS-221) N N N H N 3 N 3 N 3 N 3
Yield: 69 %. 1 H NMR (300 MHz, CDCl3): δ = 8.28 (d, J = 4.80 Hz, 2H), 6.54 (t, J = 4.80 Hz, 1H), 5.30 (Br s, 1H), 3.52 (m, 2H), 3.42 (t, J = 6.57 Hz, 2H), 1.90 (m, 2H). 1-(3-Azidopropyl)-2-hydroxy-2-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin- 4-ium bromide (BS-230) N Br N N OH Yield: 72 %. 1 H NMR (300 MHz, DMSO-d6) : δ = 9.05 (m, 2H), 7.93 (s, 1H), 7.80 (m, 2H), 7.48 (m, 3H), 7.37 (t, J = 4.86 Hz, 1H), 4.95 (m, 2H), 3.41 (m, 4H), 1.64 (m, 2H). 13 C NMR (75.5 MHz, DMSO-d6): δ = 167.4, 154.6, 148.2, 138.1, 129.3, 128.4 (×2), 126.9 (×2), 111.4, 90.6, 62.7, 47.9, 38.2, 27.0. 1-(2-Azidoethyl)-2-hydroxy-2-phenyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4ium bromide (BS-227) N Br N N OH Yield: 75 %. 1 H NMR (300 MHz, DMSO-d6) : δ = 9.02 (m, 2H), 7.99 (s, 1H), 7.80 (m, 2H), 7.49 (m, 3H), 7.41 (t, J = 4.92 Hz, 1H), 4.95 (m, 2H), 3.38 (m, 4H). 13 C NMR (75.5 MHz, DMSO-d6): δ = 167.5, 154.7, 148.4, 137.8, 129.4, 128.4 (×2), 126.9 (×2), 111.8, 90.6, 62.8, 48.1 (×2). 1-(2-Azidoethyl)-2-hydroxy-2-(naphthalen-1-yl)-2,3-dihydro-1H-imidazo[1,2a]pyrimidin-4-ium bromide (BS-271) N Br N N OH N 3 N 3 N 3
Page 1 and 2:
Saurashtra University Re - Accredit
Page 3:
JANUARY-2011 Statement under O. Ph.
Page 7 and 8:
Acknowledgment This thesis arose in
Page 9 and 10:
since I was a child. My Mother Hans
Page 11 and 12:
CHAPTER - 2 Microwave Assisted Synt
Page 13 and 14:
5.5 Results and discussion 156 5.6
Page 15 and 16:
Ms Mesyl MW Microwave NBS N-bromosu
Page 17 and 18:
1. Microwave Assisted Organic Synth
Page 19 and 20:
1.4 Heating Mechanism In microwave
Page 21 and 22:
1.5. Effects of solvents Every solv
Page 23 and 24:
1.7 Application of microwave in org
Page 25 and 26:
aromatic amines, Lancini’s group
Page 27 and 28:
1.9 2-Aminoimidazole Alkaloids The
Page 29 and 30:
Recently group of Erik 83 described
Page 31 and 32:
1.10 Methods for the preparation of
Page 33 and 34:
R 1 O X R 2 NH 2 H 2N NAc R 1 HN R
Page 35 and 36:
this manifold, was reported in 1925
Page 37 and 38:
Another route to 4(5)-acyl-2-amino-
Page 39 and 40:
this series of compounds against th
Page 41 and 42:
documented. Extra care is needed be
Page 43 and 44:
Very recently the research group of
Page 45 and 46:
OH a,b O N H2N N Boc N 3 H N R N N
Page 47 and 48:
1.12.2 Biofilm Growth Cycle 1) Plan
Page 49 and 50:
can survive both the onslaught of a
Page 51 and 52:
[26] Leadbeater, N. E. (2004) Chemi
Page 53 and 54:
[86] Kreutzberger, A. (1962) J. Org
Page 55 and 56:
Microwave Assisted Synthesis & Stru
Page 57 and 58:
2.1 Introduction As described in ch
Page 59 and 60:
2.3 Proposed Mechanism: Regarding t
Page 61 and 62:
No. 12 60 120 traces 84 a All react
Page 63 and 64:
the development of biofilm related
Page 65 and 66:
In first instance, a series of 2-hy
Page 67 and 68:
Br N N N R 1 OH Br N N N R 1 OH Fig
Page 69 and 70:
do have a very strong effect agains
Page 71 and 72:
2.6 Conclusion In the present study
Page 73 and 74:
2.8 Biological assays 2.8.1 Static
Page 75 and 76:
2.9 Experimental protocol: 2.9.1 Ge
Page 77 and 78:
temperature of 80 °C and a maximum
Page 79 and 80:
29.5,29.4, 29.2, 27.0, 22.6, 14.1.
Page 81 and 82:
Yield: 78 %. 1 H NMR (300 MHz, CDCl
Page 83 and 84:
N Br N N C 14H 29 OH Yield: 72 %. 1
Page 85 and 86:
(75.5 MHz, CDCl3): δ = 167.7, 154.
Page 87 and 88:
N Br N N C 14H 29 OH Cl Yield: 90 %
Page 89 and 90:
2-(3,4-Dichlorophenyl)-2-hydroxy-1-
Page 91 and 92:
N Br N N C 8H 17 OH NO 2 Yield: 49
Page 93 and 94:
C3H7 HN N N H Cl Cl Yield : 70 %. 1
Page 95 and 96:
(s, 1H), 3.16 (s, 3H), 1.80 (m, 2H)
Page 97 and 98:
5-(4’-Nitrobiphenyl-4-yl)-N-octyl
Page 99 and 100: 2.11 Representative NMR spectra 2.1
Page 101 and 102: 2.11.3 10.4329 0.7429 151.5720 10.0
Page 103 and 104: [21] Matz C, McDougald D, Moreno A.
Page 105 and 106: Chapter-3 Structure Activity Relati
Page 107 and 108: imidazoles, where the addition of a
Page 109 and 110: 3.4 Result and Discussion It was fo
Page 111 and 112: No. H 2N Compound Code N N C8H17 R1
Page 113 and 114: medium used in the set-up to monito
Page 115 and 116: H 2N N N N H2N N R R Figure-1 Effec
Page 117 and 118: 3.5.3 Cyclo-alkyl 2-aminoimidazoles
Page 119 and 120: 3.6. Conclusion In the present stud
Page 121 and 122: 3.8. Experimental protocols 3.8.1 G
Page 123 and 124: 122.6, 54.6, 33.3(×2), 27.3 (×2),
Page 125 and 126: Yield: 52 %. 1 H NMR (300 MHz, CDCl
Page 127 and 128: 5-(4-Chlorophenyl)-1-cyclooctyl-1H-
Page 129 and 130: Yield: 50 %. Mp: 76-78 ° C. 1 H NM
Page 131 and 132: 5-(4-Chlorophenyl)-1-cyclobutyl-1H-
Page 133 and 134: Yield: 66%. 1 H NMR (300 MHz, CDCl3
Page 135 and 136: 3.10 Representative NMR spectra 3.1
Page 137 and 138: 3.11 References [1] (a) Alvi K. A,
Page 139 and 140: Copper Catalyzed Microwave Assisted
Page 141 and 142: 4.1 Introduction There are only a f
Page 143 and 144: (Table-1, No- 6). Next reaction tem
Page 145 and 146: No. Product, Yield b (%) No. Produc
Page 147 and 148: 4.4 Possible Mechanism Regarding th
Page 149: 4.7 Experimental protocols 4.7.1 Ge
Page 153 and 154: 1-(3-Azidopropyl)-2-(3,4-dichloroph
Page 155 and 156: Yield: 84 %. 1 H NMR (300 MHz, DMSO
Page 161 and 162: 1H), 1.66 (m, 6H), 1.70 (m, 2H). 13
Page 163 and 164: 5.48 Hz, 2H), 3.59 (m, 2H), 3.16 (d
Page 165 and 166: 4.10 References [1] For a general r
Page 167 and 168: Crystal and Molecular Structure Ana
Page 169 and 170: 5.1 Introduction The membrane efflu
Page 171 and 172: oscillation range of 5˚ and proces
Page 173 and 174: C12-C13 1.372(4) C32-C37 1.390(3) C
Page 175 and 176: Fig.-3: Packing of the molecules wh
Page 177 and 178: 1 H NMR (400 MHz CDCl3): δ = 7.57-
Page 179 and 180: 5.9.2 13 C spectra of bs-DP-7
Page 181 and 182: SUMMARY The work represented in the
Page 183 and 184: CONFERENCES/SEMINARS/WORKSHOPS ATTE
Page 185: PUBLICATIONS [1] One-Pot Microwave-
Page 200 and 201:
Scheme 2 Competitive formation of 1
Page 202 and 203:
Table 2 continued 9 10 11 12 N hydr
Page 204:
8. Colson G, Raboult L, Lavelle F,
show all

Download (8Mb) - Etheses - Saurashtra University

Create successful ePaper yourself

Delete template?

Save as template?