Download (8Mb) - Etheses - Saurashtra University
Download (8Mb) - Etheses - Saurashtra University
Download (8Mb) - Etheses - Saurashtra University
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
12 2 100 °C - -<br />
13 2 100 °C Cu Powder (200 mesh) Traces<br />
14 e - f 25 °C Cu(Oac)2, 5 24<br />
a<br />
All reactions were run on a 0.7 mmol scale of 3, applying phenyl acetylene (1.2<br />
equiv) in ethanol: water (4:1, 1 mL) under microwave irradiation. The mixture was<br />
irradiated in a sealed tube (CEM Discover @ ) at a ceiling temperature of 100 o C and 35<br />
W maximum power for the stipulated time. b isolated yields. c 1.0 equiv of<br />
NH2NH2.H2O used. d 5.0 equiv of NH2NH2.H2O used. e reaction carried out at room<br />
temperature. f time 24 h.<br />
Table-1: Copper Catalyzed One-Pot protocol: Catalyst, equiv of hydrazine, reaction<br />
time and Temperature Effects on the model reaction to obtain 2-AI-T scaffold a .<br />
4.3 Results and Discussion<br />
Encouraged by these findings, the scope of this protocol was further explored. An<br />
array of hydroxy salts 3 (a-j) (Table-2) were reacted with various acetylene using our<br />
optimized conditions. In most cases, the reactions proceeded well affording the one<br />
pot product in good to excellent yield (Table-2)<br />
R 2<br />
N<br />
1<br />
+<br />
N<br />
Br<br />
2<br />
N<br />
H<br />
O<br />
R 1<br />
N 3<br />
n<br />
MeCN, 75 o C,<br />
3 Hrs<br />
R 3<br />
N N<br />
n<br />
3<br />
N<br />
Br N<br />
R OH<br />
2 R1 Cu(OAc) 2 (5 mol. %)<br />
MW. 100 o N2H4 C<br />
3 {a-j}<br />
2-5 min, 85-90 %<br />
One-pot Microwave-assisted<br />
R 2<br />
R 1<br />
N<br />
N<br />
H<br />
NH<br />
N<br />
N R3 N<br />
n<br />
4 {a-v}