MHz, CDCl3): δ =148.4, 131.2, 130.0, 129.0 (×2), 128.5 (×2), 127.3, 122.6, 55.1, 31.2(×2), 25.9 (×2), 25.1. HRMS (EI): C15H19N3, calcd 241.1579, found: 241.1589. 1-Cyclobutyl-5-phenyl-1H-imidazol-2-amine (BS-081) H 2N N N Yield: 47%. Mp: 77-79 ° C. 1 H NMR (300 MHz, CDCl3): δ = 7.41-7.28 (m, 5H), 6.58 (s, 1H), 4.61 (m, 1H), 4.07 (br, 2H), 2.51 (m, 2H), 2.27 (m, 2H), 1.75 (m, 2H). 13 C NMR (75.5 MHz, CDCl3): δ =149.1, 131.3, 129.7, 128.6 (×2), 128.3 (×2), 127.1, 122.9, 49.2, 29.5 (×2), 15.0. HRMS (EI): C13H15N3, calcd 213.1266, found: 213.1268. 1-Pentyl-5-phenyl-1H-imidazol-2-amine (BS-085) H 2N N N C5H11 Yield: 53 %. Mp: 123-125 ° C. 1 H NMR (300 MHz, CDCl3): δ = 7.46-7.29 (m, 5H), 6.67 (s, 1H), 4.00 (br, 2H), 3.75 (t, J = 7.5 Hz, 2H), 1.59 (m, 2H), 1.19 (m, 4H), 0.81 (t, J = 6.7 Hz, 3H). 13 C NMR (75.5 MHz, CDCl3): δ =149.0, 131.0, 129.4, 128.6 (×2), 128.2 (×2), 127.2, 122.8, 43.1, 29.2, 28.6, 22.0, 13.8. HRMS (EI): C14H19N3, calcd 229.1579, found: 229.1594. 5-(4-Chlorophenyl)-1-cyclododecyl-1H-imidazol-2-amine (BS-116) H 2N N N Yield: 42 %. Mp: 221-223 ° C 1 H NMR (300 MHz, CDCl3): δ = 7.38 (m, 5H), 6.59 (s, 1H), 4.16 (m, 1H), 3.98 (br, 2H), 1.88 (m, 5H), 1.22(m, 14H), 0.90 (m, 3H). 13 C NMR (75.5 MHz, CDCl3): δ =148.4, 131.4, 131.2, 129.8 (×2), 128.3 (×2), 127.5, 122.1, 50.0, 29.1(×2), 24.0 (×2), 23.9 (×2), 22.6 (×2), 21.9 (×2), 21.5. HRMS (EI):C21H31N3, calcd 325.2518, found: 325.2118. Cl
5-(4-Chlorophenyl)-1-cyclooctyl-1H-imidazol-2-amine (BS-117) H 2N N N Yield: 55 %. Mp: 207-209 ° C. 1 H NMR (300 MHz, CDCl3): δ = 7.37 (d, J = 8.4 Hz, 2H), 7.20 (d, J = 8.4 Hz, 2H), 6.59 (s, 1H), 4.18 (m, 1H), 4.02 (br, 2H), 2.12 (m, 2H), 1.85 (m, 4H), 1.50 (m, 7H), 1.25 (m, 1H). 13 C NMR (75.5 MHz, CDCl3): δ =148.6, 131.1, 130.0 (× 2), 129.7, 128.7 (×2), 128.3, 123.4, 56.7, 33.3(×2), 27.2 (×3), 25.7 (×2). HRMS (EI): C17H22ClN3, calcd 303.1502, found: 303.1519. 5-(4-Chlorophenyl)-1-cycloheptyl-1H-imidazol-2-amine (BS-118) H 2N N N Yield: 51 %. Mp: 180-182 ° C. 1 H NMR (300 MHz, CDCl3): δ = 7.36 (d, J = 8.4 Hz, 2H), 7.18 (d, J = 8.4 Hz, 2H), 6.59 (s, 1H), 4.00 (m, 3H), 2.12 (m, 2H), 1.92 (m, 2H), 1.75 (m, 2H), 1.55 (m, 6H). 13 C NMR (75.5 MHz, CDCl3): δ =148.6, 131.1, 130.0 (×2), 129.7, 128.7 (×2), 128.3, 123.4, 56.7, 33.3(×2), 27.2 (×2), 25.7 (×2). HRMS (EI): C16H20ClN3, calcd 289.1346, found: 289.1364. 5-(4-Chlorophenyl)-1-heptyl-1H-imidazol-2-amine (BS-119) H 2N N N C7H15 Yield: 54 %. Mp: 80-82 ° C. 1 H NMR (300 MHz, CDCl3): δ = 7.35 (d, J = 8.4 Hz, 2H), 7.23 (d, J = 8.4 Hz, 2H), 6.66 (s, 1H), 4.02 (br, 2H), 3.72(t, J = 7.5 Hz, 2H), 1.57 (m, 2H), 1.18 (m, 8H), 0.84 (t, J = 6.5 Hz, 3H). 13 C NMR (75.5 MHz, CDCl3): δ =149.4, 133.0, 129.6, 129.3 (×2), 128.8 (×2), 128.1, 123.5, 43.1, 31.5, 29.5, 28.6, 26.4, 22.5, 14.2. HRMS (EI): C16H22ClN3, calcd 291.1502, found: 291.1507. Cl Cl Cl
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Saurashtra University Re - Accredit
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JANUARY-2011 Statement under O. Ph.
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Acknowledgment This thesis arose in
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since I was a child. My Mother Hans
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CHAPTER - 2 Microwave Assisted Synt
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5.5 Results and discussion 156 5.6
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Ms Mesyl MW Microwave NBS N-bromosu
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1. Microwave Assisted Organic Synth
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1.4 Heating Mechanism In microwave
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1.5. Effects of solvents Every solv
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1.7 Application of microwave in org
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aromatic amines, Lancini’s group
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1.9 2-Aminoimidazole Alkaloids The
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Recently group of Erik 83 described
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1.10 Methods for the preparation of
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R 1 O X R 2 NH 2 H 2N NAc R 1 HN R
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this manifold, was reported in 1925
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Another route to 4(5)-acyl-2-amino-
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this series of compounds against th
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documented. Extra care is needed be
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Very recently the research group of
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OH a,b O N H2N N Boc N 3 H N R N N
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1.12.2 Biofilm Growth Cycle 1) Plan
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can survive both the onslaught of a
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[26] Leadbeater, N. E. (2004) Chemi
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[86] Kreutzberger, A. (1962) J. Org
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Microwave Assisted Synthesis & Stru
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2.1 Introduction As described in ch
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2.3 Proposed Mechanism: Regarding t
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No. 12 60 120 traces 84 a All react
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the development of biofilm related
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In first instance, a series of 2-hy
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Br N N N R 1 OH Br N N N R 1 OH Fig
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do have a very strong effect agains
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2.6 Conclusion In the present study
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2.8 Biological assays 2.8.1 Static
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1 H NMR (400 MHz CDCl3): δ = 7.57-
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5.9.2 13 C spectra of bs-DP-7
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SUMMARY The work represented in the
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CONFERENCES/SEMINARS/WORKSHOPS ATTE
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PUBLICATIONS [1] One-Pot Microwave-
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Scheme 2 Competitive formation of 1
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Table 2 continued 9 10 11 12 N hydr
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8. Colson G, Raboult L, Lavelle F,