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No.<br />
Compound<br />
Code<br />
R1<br />
H 2N<br />
N<br />
N<br />
R 1<br />
R2<br />
R 2<br />
S. Typhimurium<br />
IC50<br />
P. aeruginosa<br />
IC50<br />
1 A-Cy-1 c-Pr H 89.6 35.0<br />
2 A-Cy-2 c-Bu H 116.3 19.9<br />
3 A-Cy-3 c-Pen H 70.7 12.6<br />
4 A-Cy-4 c-Hex H 85.1 4.6<br />
5 A-Cy-5 c-Hep H 26.8 14.2<br />
6 A-Cy-6 c-Oct H 40.4 4.5<br />
7 A-Cy-7 c-Dod H 14.5 >800<br />
8 B-Cy-1 c-Pr Cl 54.8 13.0<br />
9 B-Cy-2 c-Bu Cl 11.5 6.0<br />
10 B-Cy-3 c-Hex Cl 33.2 11.2<br />
11 B-Cy-4 c-Hep Cl 15.6 4.0<br />
12 B-Cy-5 c-Oct Cl 12.8 48.6<br />
13 B-Cy-6 c-Dod Cl 120.2 >800<br />
IC50: concentration of inhibitor needed to inhibit biofilm formation by 50%.<br />
Explanation Note: Number of compound code is also corresponding to the ring size of<br />
cyclic substitution at R1 position. (ie. A-Cy-1 is Cyclopropyl substituted )<br />
Table-5: Influence of N1-cyclo-alkyl-2-aminoimidazoles on the biofilm formation<br />
and the planktonic growth of S. Typhimurium and P. aeruginosa PA14 at 25°C.