Download (8Mb) - Etheses - Saurashtra University

CHAPTER – 2
Microwave Assisted Synthesis & Structure Activity Relationship of 2-Hydroxy-2phenyl-2,3-dihydro-imidazo[1,2-a]pyrimidinium
Salts and 2N-Substituted 4(5)-
Phenyl-2-Amino-1H-imidazoles as Inhibitors of the Biofilm Formation by
Salmonella Typhimurium and Pseudomonas aeruginosa
2.1 Introduction 40
2.2 Reaction scheme 41
2.3 Proposed Mechanism 42
2.4 Results and discussion 43
2.5 Biofilm activity 50
2.5.1 2N-substituted 2-aminopyrimidines 48
2.5.2 2-hydroxy-2,3-dihydro-imidazopyrimidinium salts 48
2.5.2.1 n-Alkyl or iso-alkyl substituents at 1-position 48
2.5.2.2 Further Modification in the most active core structure 51
2.5.2.3 Cyclo-alkyl substituents at 1-position 53
2.5.3 2N-substituted 2-aminoimidazoles 54
2.6 Conclusion 56
2.7 Experimental 57
2.8 Biological Assays 58
2.9 Experimental Protocols 60
2.10 Spectral Characterization 62
2.11 Representative NMR spectra 87
2.12 References 90
CHAPTER – 3
Structure Activity Relationship of N1-Substituted 2-Aminoimidazoles as
Inhibitors of Biofilm Formation by Salmonella Typhimurium and Pseudomonas
aeruginosa
3.1 Introduction 93
3.2 Reaction scheme 94
3.3 Proposed Mechanism 95
3.4 Results and discussion 96