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KCE reports vol. 6A Prenatale zorg 67
Study Ref Population Intervention Outcomes Results Comments Study
type
EL
Steer et 4 [271] 153,602 pregnancies in Retrospective analysis of Retrospective analysis of Maximum mean birth weight
CSS 3
al., 1995
North West Thames information on database to information on database (3483 g µ 565) achieved with
region, England
determine association of to determine association lowest Hb 8.5 g/dl to 9.5 g/dl
lowest Hb level in pregnancy of lowest Hb level in
and birth weight and rates of pregnancy and birth Lowest incidence of low birth
low birth weight and preterm weight and rates of low weight and preterm labour
delivery in different ethnic birth weight and occurred with lowest Hb 9.5
groups
preterm delivery in
different ethnic groups
g/dl to 10.5 g/dl
Similar for all ethnic groups
Does iron supplementation during pregnancy improve perinatal outcomes?
Study Ref Population Intervention Outcomes Results Comments Study
Mahomed,
2001
4 [76] 20 RCTs Iron vs. no iron or placebo
(except one trial: selective
vs. routine iron) in pregnant
women
Haemoglobin
Measures of iron
status
Pregnancy
outcome
Side effects of
treatment
Low (< 10 g or 10.5 g)
predelivery Hb (12 RCTs, n =
1802): Peto OR 0.15 (95% CI 0.11
to 0.20)
Low predelivery serum iron (4
RCTs, n = 726): Peto OR 0.19
(95% CI 0.12 to 0.29)
Low (< 10 mg/dl) predelivery
serum ferritin (4 RCTs, n = 481):
Peto OR 0.12 (95% CI 0.08 to
0.17)
Caesarean section (1 RCT, n =
2694): Peto OR 1.36 (95% CI 1.04
to 1.78)
Blood transfusion (1 RCT, n =
2694): Peto OR 1.68 (95% CI 1.05
All pregnancy outcome
results were from the trial
that compared selective vs.
routine iron in pregnancy
EL
type
SR 1a