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KCE reports vol. 6A Prenatale zorg 63
What is the sensitivity, specificity and positive predictive value of a clinical breast examination (CBE) and what is the effect of this
examination on the mortality rate?
Study Ref Population Intervention Outcomes Results Comments Stud
y
type
EL
Humpre 7 8 RCT´s SR to synthesize new data Sensitivity of CBE 40%-69%
No trial has compared SR 1a
y et al.,
on breast cancer screening
CBE alone with no
2002
for the US Preventive
Services Task Force
Specificity of CBE 88%-99%
screening
Positive predictive value of
CBE
4%-50%
(mammography and
interval cancer were used
as the criterion standard)
Mortality reduction
associated with the use of
CBE and mammography
29% and 14%