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KCE reports vol. 6A Prenatale zorg 58
Study Ref Population Intervention Outcomes Results Comments Study
type
after 20th week K5 (n = 117)
women were found to have severe Blinded endpoint analysis, but
of pregnancy in
Requirements for diastolic hypertension with K4: 34 patients, doctors and midwives
Australia
antihypertensive (33%) vs. 20 (17%), p = 0.006) were aware of RCT random
treatment
No significant difference in number
allocation
of episodes of severe
Severe hypertension defined as
hypertension, however more systolic greater than or equal
women were found to have severe to 170mm Hg, diastolic greater
diastolic hypertension with K4: 34
(33%) vs. 20 (17%), p = 0.006)
than or equal to 110mm Hg
2. Weight and BMI
Laboratory data
(including serum
creatinine, uric acid,
aspartate
aminotransferase,
platelet count and
haemoglobin)
Birth weight
Fetal growth
restriction
Perinatal mortality
Eclampsia
Maternal death
No significant difference in
proportion of women who needed
antihypertensive treatment or in
laboratory data
No significant difference in birth
weight, fetal growth restriction,
prolonged pregnancy, or perinatal
mortality
No cases of eclampsia or maternal
death
Wat are the risks associated with a high prepregnancy BMI/ weight?
Study Ref Population Intervention Outcomes Results Comments Study
Duckitt,
2003
4 [512] Pregnant
women
Systematic review of studies
on risk factors for pre-eclampsia
to July 2002
Parity
Age
Nulliparity OR 2.71, 95% CI
1.16 to 6.34 (14 studies)
type
CH &
CCS
EL
EL
2b
& 3