Download het volledig rapport (302 p.) - KCE

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<strong>KCE</strong> reports vol. 6A Prenatale zorg 244 Study Ref Population Intervention Outcomes Results Comments Study type zinc (30 mg), or multiple iron) or micronutrients (MNs; the iron + zinc foregoing plus 10 microg vitamin had a D, 10 mg vitamin E, 1.6 mg consistent thiamine, 1.8 mg riboflavin, 2.2 mg pattern of vitamin B-6, 2.6 microg vitamin B- 15-20% 12, 100 mg vitamin C, 64 microg lower 3-mo vitamin K, 20 mg niacin, 2 mg Cu, mortality; and 100 mg Mg). The control this pattern group received vitamin A only. l was not observed with MNs Ramakrishnan et al., 2003 142 Mexico rural area, 873 PeopleÊs league of health, 1942 women 143 London 1938-9 Iron 60 mg only vs iron + micronutriments Iron + calcium + iodine + manganese + copper + vitamin C + vitamin B complex + fish oil Birth weight birth length Toxaemia Gestational age Stillbirth NS RCT 1b Decrease Increase Decrease RCT (not blind) EL 1b
<strong>KCE</strong> reports vol. 6A Prenatale zorg 245 Prévention de lÊimmunisation Rhésus Routine antenatal administration of anti-D Study Ref Population Intervention Outcomes Results Comments Study Jones et al, 2004 Chilcott et al, 2004 144 11 controlled studies of routine antenatal anti-D prophylaxis including 1 RCT. 30 325 intervention & 18 558 control 145 Cost effectiveness modelling From 250 to 2*1500 IU anti-D At 28 or 28 and 34 weeks vs nil Postnatal anti- D immunisation Immunisation rate: 1.48% in controls and 0.48 in treated. Cost effective. Routine antenatal anti-D prophylaxis provides a cost effective intervention for preventing haemolytic disease of the newborn in the pregnancies of women who are RhD-negative. Low dose / late administration less effective Historical and geographical controls type EL SR 1b, 2a
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