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KCE reports vol. 6A Prenatale zorg 241
Does periconceptional (before pregnancy and continuing through the first three months) folate supplementation has a strong protective
effect against neural tube defects?
Study Ref Populatio Interventi Outcomes Results Comments Study E
n on
type L
Lumley et al., 2000 13 4 RCTs Multivitam Neural tube defects Incidence of NTDs : RR 0.28 (95% Periconceptional folate supplementation has SR 1a
3 6425 ins or/and (NTDs)
CI 0.13 to 0.58). Folate
a strong protective effect against neural tube
Date of Most Recent women folate vs. spontaneous abortion; supplementation did not defects.
Update: 31-May-2001
placebo multiple pregnancy; significantly increase miscarriage,
preterm birth; ectopic pregnancy or stillbirth,
perinatal and infant although there was a possible
mortality.
increase in multiple gestation.
Multivitamins alone were not
associated with prevention of
neural tube defects and did not
produce additional preventive
effects when given with folate.
2.e.Vitamin B6
Does routine vitamin B6 (pyridoxine) supplementation during pregnancy improve maternal and perinatal outcomes?
Study Ref Population Intervention Outcomes Results Comments Study
Mahomed et al., 2004
Date of most recent
substantive
amendment: 21
October 1996
134 1 RCT
371
women
20 mg pyridoxine vs.
placebo & vs.
multivitamins
capsules vs. placebo:
OR=0.63[0.41-0.95]
lozenges vs. placebo:
OR=0.33[0.22-0.51]
Decayedmissing-filled
teeth
capsules vs. placebo:
OR=0.63[0.41-0.95]
lozenges vs. placebo:
OR=0.33[0.22-0.51]
There is not enough evidence to evaluate pyridoxine
supplementation during pregnancy, although the
results of one trial suggest that it may have a
beneficial effect on dental decay.
EL
type
SR 1a