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<strong>KCE</strong> reports vol. 6A Prenatale zorg 240 2. c. Vitamin D Does vitamin D supplementation during pregnancy improve maternal and perinatal outcomes? Study Ref Population Intervention Outcomes Results Comments Study Mahomed et al., 2000 Date of most recent substantive amendment: 16 October 1998 Grootjans-Geerts and Wielders, 2002 129 2 trials = 232 women Vit D vs. nil vs. placebo vs. 5mg at 32 weeks Datta et al., 2002 131 non-European ethnic minorities in South Wales 2.d. Vitamin M or folic acid Birth weight Neonatal hypocalcemia Craniotabes 130 Netherlands Observational Survey of Vitamin D deficiency Detection of deficiency & 800 IU if below cut off Survey & treatment Trend to increase Trend to decrease Trend to decrease 82% of veiled women deficient 50% deficient All treated normalised There is not enough evidence to evaluate the effects of vitamin D supplementation during pregnancy. EL type SR 1a !!! SU 3 Does routine folic acid supplementation during pregnancy improve maternal and perinatal outcomes? Study Ref Population Intervention Outcomes Results Comments Study Mahomed, 2004 Date of most recent substantive amendment: 21 May 1997 132 21 RCTs 3114 women At least 500 g daily of folate during pregnancy vs. placebo or nil Haemoglobin Abruptio FGR OR 0.6 [0.5- 0.7] OR 0.4 [0.1- 1.4] OR 0.7[0.5- 1.0] ISNR 2 EL type SR 1a
<strong>KCE</strong> reports vol. 6A Prenatale zorg 241 Does periconceptional (before pregnancy and continuing through the first three months) folate supplementation has a strong protective effect against neural tube defects? Study Ref Populatio Interventi Outcomes Results Comments Study E n on type L Lumley et al., 2000 13 4 RCTs Multivitam Neural tube defects Incidence of NTDs : RR 0.28 (95% Periconceptional folate supplementation has SR 1a 3 6425 ins or/and (NTDs) CI 0.13 to 0.58). Folate a strong protective effect against neural tube Date of Most Recent women folate vs. spontaneous abortion; supplementation did not defects. Update: 31-May-2001 placebo multiple pregnancy; significantly increase miscarriage, preterm birth; ectopic pregnancy or stillbirth, perinatal and infant although there was a possible mortality. increase in multiple gestation. Multivitamins alone were not associated with prevention of neural tube defects and did not produce additional preventive effects when given with folate. 2.e.Vitamin B6 Does routine vitamin B6 (pyridoxine) supplementation during pregnancy improve maternal and perinatal outcomes? Study Ref Population Intervention Outcomes Results Comments Study Mahomed et al., 2004 Date of most recent substantive amendment: 21 October 1996 134 1 RCT 371 women 20 mg pyridoxine vs. placebo & vs. multivitamins capsules vs. placebo: OR=0.63[0.41-0.95] lozenges vs. placebo: OR=0.33[0.22-0.51] Decayedmissing-filled teeth capsules vs. placebo: OR=0.63[0.41-0.95] lozenges vs. placebo: OR=0.33[0.22-0.51] There is not enough evidence to evaluate pyridoxine supplementation during pregnancy, although the results of one trial suggest that it may have a beneficial effect on dental decay. EL type SR 1a
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