Download het volledig rapport (302 p.) - KCE

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<strong>KCE</strong> reports vol. 6A Prenatale zorg 236 Study Ref Population Intervention Outcomes Results Comments Study type 2002 & 2004 116 deficiency not use iodized salt 1.d. Magnesium Does routine magnesium supplementation during pregnancy improve maternal, neonatal and paediatric outcomes? Study Ref Population Intervention Outcomes Results Comments Study Makrides and Crowther, 2001 117 7 RCTs, 2689 women 1.e. Zinc Magnesium orally administered and commenced prior to the 25th week of gestation vs. placebo (216mg, 365mg, 500mg, 2g/day, 15mmol). Maternal morbidity, neonatal morbidity, Neonatal mortality. SBP, induced hypertension, PET, maternal hospitalisation, ante & post-partum HH, length of labour, GA at birth, preterm birth, BW, LBW, small for GA, and admission ICU . Maternal side effects: gastrointestinal. Preterm birth (
<strong>KCE</strong> reports vol. 6A Prenatale zorg 237 Study Ref Population Intervention Outcomes Results Comments Study type placebo or no zinc Abnormalities of labour, other differences were detected between There is insufficient evidence during pregnancy. caesarean section, groups of women who had zinc to evaluate fully the affect of (20 mg zinc). preterm delivery. supplementation and those who had either zinc supplementation during placebo or no zinc during pregnancy. pregnancy Does routine zinc supplementation during pregnancy affect maturation of fetal cardiac patterns? Study Ref Population Intervention Outcomes Results Comments Study Merialdi et al., 2004 119 242 lowincome Peruvian women 60 mg iron, 250 g folic acid with or without 25 mg zinc at 10 to 16 weeks' gestation Fetal heart rate (FHR, variability [HRV], number of accelerations) and movements (number and amplitude of movement bouts, time spent moving) Zinc supplementation was associated with lower FHR, greater number of accelerations, and greater HRV. Supplementation effects on HRV and accelerations were more pronounced after 28 weeks' gestation. No differences in motor activity were observed. Trial in developing country with zinc-deficient mothers Does routine zinc supplementation during pregnancy is positively associated with fetal growth as assessed by ultrasonography? Study Ref Population Intervention Outcomes Results Comments Study Merialdi et al., 2004 120 242 lowincome Peruvian women 60 mg iron, 250 g folic acid with or without 25 mg zinc at 10 to 16 weeks' gestation fetal head circumference, biparietal diameter, abdominal circumference, and femur diaphysis length at 20, 24, 28, 32, 36, and 38 wk of gestation Femur diaphysis length was greater in fetuses whose mothers received zinc supplements (P < 0.05) and the difference tended to increase with gestational age. No significant differences by supplement type were observed for the other anatomical sites measured Trial in developing country with zinc-deficient mothers EL EL type RCT 1b EL type RCT 1b
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