Download het volledig rapport (302 p.) - KCE

KCE reports vol. 6A Prenatale zorg 233
7.4.2. Evidence table
Voedingssupplementen
1. Minerals
The following minerals have been considered: calcium, iron (with and without folic acid), iodine, magnesium, zinc and fluoride. We considered that for other
minerals which have been used in supplementation such as copper, selenium, etc), there was neither compelling evidence, nor a pressure to consider their use
derived from observational data or animal research. Also, in agreement with the Cochrane Systematic Review, we considered that a purely biological effect
was not sufficient, but that a clinical effect was warranted.
1.a. Calcium
Does routine calcium supplementation improve maternal and perinatal outcomes?
Study Ref Populatio Intervention Outcomes Results Comments Study E
n
type L
Atallah et al., 2003
10 11 RCTs At least one gram daily of PIH
OR 0.6 Heterogenity; effect most marked if risk SR 1a
8 6894 calcium during pregnancy vs. PET
[0.4-0.8] patients or low calcium intake
Date of most recent substantive women placebo
PTL
OR 0.4
amendment: 15 October 2001
Child BP [0.2-0.6]
OR
0.7[0.4-
1.0]
OR 0.6
[0.4-0.9]