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<strong>KCE</strong> reports vol. 8A Prenatale zorg 232 7.4. VOEDINGSSUPPLEMENTEN EN ANTI-D PROFYLAXIS TER PREVENTIE VAN RHESUS-ISO-IMMUNISATIE : ZOEKSTRATEGIE EN EVIDENCE TABLES 7.4.1. Zoekstrategie La recherche bibliographique a été faite par interrogation des bases de données bibliographique MEDLINE, EMBASE. Seul les publications de langue française, néerlandaise et anglaise ont été retenues. La combinaison des termes dÊéquation 1 et dÊéquation 2 ou 3 ou 4 suivants ont étés utilisés : Équation 1 : ÂLes compléments ou vitamine A , vitamine C vitamine E, vitamine D, vitamine B6, fer, calcium, acide folique, magnésium, fluorure, sélénium, zinc, iode, huile de poissonsÊ et Âgrossesse normaleÊ Équation 2 : Recommandation, conférences de consensus compris : Practice Guideline(s) ou Guideline(s), Health Planning Guidelines ou Recommendation(s) (titre) OU Consensus Development Conferences, OU Consensus Conference(s) OU Consensus Statement(s). Équation 3 : Revus de littérature, meta-analyses compris : Meta- Analyses OU Review Literature OU Systematic Review OU Systematic Review. Équation 4 : Randomized Controlled Trial(s) OU Controlled >Clinical trial(s) OU Double-Blind Method OU Double Blind Procedure Ou Random Allocation Ou Comparative Study OU Randomization OU Comparison OU Random OU cross-over Studies. La recherche bibliographique a été complétée par la consultation de la Cochrane Library et des sites Internet des sociétés savantes et des agences dÊévaluation en santé. De la base documentaire utilisée par RCOG pour lÊélaboration de recommandation sur le même thème à la demande du National Institute for Clinical Excellence (NICE). 4 Cette base a été particulièrement utile pour compléter la recherche documentaire. Les recommandations sur le même term élaborées par Institute for Clinical System Improvement (ICSI) 55 et par Society of Obstetricians and Gynaecologiste of Canada (SOGC) 56 ont été consultées.
<strong>KCE</strong> reports vol. 6A Prenatale zorg 233 7.4.2. Evidence table Voedingssupplementen 1. Minerals The following minerals have been considered: calcium, iron (with and without folic acid), iodine, magnesium, zinc and fluoride. We considered that for other minerals which have been used in supplementation such as copper, selenium, etc), there was neither compelling evidence, nor a pressure to consider their use derived from observational data or animal research. Also, in agreement with the Cochrane Systematic Review, we considered that a purely biological effect was not sufficient, but that a clinical effect was warranted. 1.a. Calcium Does routine calcium supplementation improve maternal and perinatal outcomes? Study Ref Populatio Intervention Outcomes Results Comments Study E n type L Atallah et al., 2003 10 11 RCTs At least one gram daily of PIH OR 0.6 Heterogenity; effect most marked if risk SR 1a 8 6894 calcium during pregnancy vs. PET [0.4-0.8] patients or low calcium intake Date of most recent substantive women placebo PTL OR 0.4 amendment: 15 October 2001 Child BP [0.2-0.6] OR 0.7[0.4- 1.0] OR 0.6 [0.4-0.9]
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