Download het volledig rapport (302 p.) - KCE

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<strong>KCE</strong> reports vol. 6A Prenatale zorg 230 Study Ref Population Intervention Outcomes Results Comments Study EL Type published studies and about 16%. If the published data from the participation rate Dutch Office of Statistics increased to 100%, (the Netherlands) screening of pairs would be financially attractive at a diagnostic take-up rate for diagnostic tests of 6% for DETS and 7% for SETS Rowl 106 Pregnant women who Cost-utility analysis Marginal cost per QUALY 57% acceptance rate for Costs were estimated in EE ey et would, potentially, benefit $ 8,290 screening 1996 US dollars al., from CF screening Evaluation of cost-benefit 1998 and savings Some variables dominated Sensitivity of screening The setting was a hospital in sensitivity analysis: test = 0.85 Evaluation of patient screening saved money The study was set in willingness to pay and generated QUALYs if providers offices with the cost of laboratory test delivery services in Comparator = no screening falls below $ 100, if the life Monroe County, USA expectance of a child with CF increases from 30 to 54 years, if the discount rate falls from 3% to 0.9% screening costs money and decreases QUALYs if the probability that an affected pregnancy will be terminated falls below 0.25 77% would not pay more than $ 25 and nearly 94% of respondents would pay less than $ 50
<strong>KCE</strong> reports vol. 6A Prenatale zorg 231 Study Ref Population Intervention Outcomes Results Comments Study Type Cuckl 107 Setting: antenatal clinics Cost-effectiveness analysis Cost per affected Under the baseline Costs of the education EE e et and general practitioners and sensitivity analysis of pregnancy detected assumptions of all relevant health al., in the UK different antenatal screening ( 20% = proportion of professionals are not 1995 programmes of CF missing information on carrier status from previous pregnancies, 20% = proportion changing partners between pregnancies, 100% = uptake of prenatal diagnosis): Sequential screening: Costs ranging from £ 40,000 to £ 90,000, depending on carrier detection rate and uptake Couple screening: Costs ranging from £ 46,000 to £104,000 included From the sensitivity analysis: 10% change in the assumed proportion of missing information alters the cost with £ 4000 10% change in the proportion with new partners has a similar effect, but only for couple screening Cost will change in proportion with uptake EL
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